ArticleScience advances2023
Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.Redox report : communications in free radical research · 2026Article
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
- GLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism.JCI insight · 2026Article
- Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease.Redox biology · 2026Article
- Provoking disulfidptosis-enhanced mitophagy by manganese-based nanoplatform via regulating cellular energy supply and redox homeostasis.Materials today. Bio · 2026Article
- Intracellular enzymatic reducing systems control receptor tyrosine kinase signaling via PTP1B.Science advances · 2026Article
- Otubain deubiquitinases: Multi-layered regulators of cell fate, development, and stress responses across kingdoms.iScience · 2026Review
- The interplay of ferroptosis and oxidative stress in pulmonary fibrosis: from mechanisms to treatment.Frontiers in cell and developmental biology · 2026Review
- Immunometabolic reprogramming and glycolysis-associated signatures in sepsis: insights from single-cell RNA sequencing and machine learning.Frontiers in immunology · 2026Article
- ACSL4-Mediated Ferroptosis and its Biological Functions and Potential Therapeutic Significance in Liver Diseases.Current pharmaceutical design · 2026Review
- Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.Bioactive materials · 2025Article
- Ferroptosis-mediated osteoclast-osteoblast crosstalk: signaling pathways governing bone remodeling in osteoporosis.Journal of orthopaedic surgery and research · 2025Review
- Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion.Redox biology · 2025Article
- Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanisms of metabolism-coupled protein modifications.Nature chemical biology · 2025Review
- Integrative analysis of transcriptome and metabolome profiling uncovers underlying mechanisms of the enhancement of the synthesis of biofilm in Sporobolomyces pararoseus NGR under acidic conditions.Microbial cell factories · 2025Article
- Ferroptosis: a novel pharmacological mechanism against multiple myeloma.Frontiers in pharmacology · 2025Review
- Study on the In Vitro and In Vivo Antioxidant Activity and Potential Mechanism ofAntioxidants (Basel, Switzerland) · 2025Article
- Ferroptosis: mechanisms and therapeutic targets.MedComm · 2024Review
- Oxidative Stress, Glutaredoxins, and Their Therapeutic Potential in Posterior Capsular Opacification.Antioxidants (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Reem AboushoushaDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-2284-2180
Jos van der VeldenDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-2451-3180
Nicholas HamiltonDepartment of Chemistry, University of Vermont, Burlington, VT 05405, USA.
Zhihua PengDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Maximilian MacPhersonDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0001-5759-3650
Cuixia EricksonDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Sheryl WhiteDepartment of Neurological Sciences, University of Vermont, Burlington, VT 05405, USA.
Emiel F M WoutersDepartment of Respiratory Medicine, NUTRIM School of nutrition and translational research in metabolism, Maastricht University Medical Center, Maastricht, Netherlands.
Niki L ReynaertDepartment of Respiratory Medicine, NUTRIM School of nutrition and translational research in metabolism, Maastricht University Medical Center, Maastricht, Netherlands.
David J SewardDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0001-5821-6187
Jianing LiDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-2735-8745
Funding
S-glutathionylation chemistry in fibrotic lung remodelingR35HL135828 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2017 to 2023
$6.5MGlutaredoxin, Glutathione Metabolism and Lung CancerR01CA273238 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Yvonne M. W. Janssen-Heininger · 2023 to 2026
$2.1MGSTP1-induced S-glutathionylation in lung cancerR01CA219156 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VELDEN, ADRIANUS (JOS)L.J. · 2017 to 2021
$1.8MStructure, Mechanism, and Regulation of PACAP/VIP GPCR SubtypesR01GM129431 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LI, JIANING · 2018 to 2022
$1.7MNCI NIH HHS R01 CA219156NCI NIH HHS R01 CA273238NHLBI NIH HHS R35 HL135828NIGMS NIH HHS R01 GM129431
Abstract
Glutathione (GSH) is a critical component of the cellular redox system that combats oxidative stress. The glutamate-cystine antiporter, system x
Indexed as
CystineGlutaredoxinsBiological TransportGlutamic AcidGlutathioneCystineGlutamic AcidGlutaredoxinsGlutathione
Identifiers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.