Evidence map›Paper›PMID 37703257›Full record

ArticlePloS one2023

Associations between tobacco and cannabis use and anxiety and depression among adults in the United States: Findings from the COVID-19 citizen science study.

Nhung Nguyen, Noah D Peyser, Jeffrey E Olgin, Mark J Pletcher, Alexis L Beatty, Madelaine F Modrow, Thomas W Carton, Rasha Khatib, Djeneba Audrey Djibo, Pamela M Ling and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 32 citations in OpenAlex.

  1. Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
  2. Article
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  9. Polysubstance use and mental health among young adults.Canadian journal of public health = Revue canadienne de sante publique · 2025
    Article
  10. Article
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  12. Prevalence and determinants of cigarette-cannabis co-use among US cancer survivors.Journal of cancer survivorship : research and practice · 2025
    Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Nhung NguyenDepartment of Medicine, Center for Tobacco Control Research and Education and Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0002-8661-9597
Noah D PeyserDepartment of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0003-4529-8325
Jeffrey E OlginDepartment of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California, United States of America.
Mark J PletcherDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0002-6966-1312
Alexis L BeattyDepartment of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California, United States of America.
Madelaine F ModrowDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.
Thomas W CartonLouisiana Public Health Institute, New Orleans, Louisiana, United States of America.
Rasha KhatibAdvocate Aurora Health, Downers Grove, Illinois, United States of America.
Djeneba Audrey DjiboCVS Health, Northbrook, Illinois, United States of America.ORCID 0000-0003-3378-0691
Pamela M LingDepartment of Medicine, Center for Tobacco Control Research and Education and Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Gregory M MarcusDepartment of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California, United States of America.
University of California, San Francisco · USAdvocate Health Care · USCVS Health (United States) · USLouisiana Public Health Institute · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
The Health ePeople Resource for Mobilized ResearchU2CEB021881 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCUS, GREGORY M, OLGIN, JEFFREY E · 2015 to 2020
$10.3M
MHC Variation in Host Response to SARS-CoV2 and COVID-19 OutcomesR01AI159260 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$4.0M
DIGITAL HEALTH SOLUTIONS FOR COVID-19: COVIDSEEKER AND COVID-19 CITIZEN SCIENCE75N91020C00039 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCUS, GREGORY · 2020 to 2020
$460k
NCATS NIH HHS UL1 TR001872NCI NIH HHS 75N91020C00039NIAID NIH HHS R01 AI159260NIBIB NIH HHS U2C EB021881
6 · The paper itself

Abstract

backgroundLittle is known about whether people who use both tobacco and cannabis (co-use) are more or less likely to have mental health disorders than single substance users or non-users. We aimed to examine associations between use of tobacco and/or cannabis with anxiety and depression.

methodsWe analyzed data from the COVID-19 Citizen Science Study, a digital cohort study, collected via online surveys during 2020-2022 from a convenience sample of 53,843 US adults (≥ 18 years old) nationwide. Past 30-day use of tobacco and cannabis was self-reported at baseline and categorized into four exclusive patterns: tobacco-only use, cannabis-only use, co-use of both substances, and non-use. Anxiety and depression were repeatedly measured in monthly surveys. To account for multiple assessments of mental health outcomes within a participant, we used Generalized Estimating Equations to examine associations between the patterns of tobacco and cannabis use with each outcome.

resultsIn the total sample (mean age 51.0 years old, 67.9% female), 4.9% reported tobacco-only use, 6.9% cannabis-only use, 1.6% co-use, and 86.6% non-use. Proportions of reporting anxiety and depression were highest for the co-use group (26.5% and 28.3%, respectively) and lowest for the non-use group (10.6% and 11.2%, respectively). Compared to non-use, the adjusted odds of mental health disorders were highest for co-use (Anxiety: OR = 1.89, 95%CI = 1.64-2.18; Depression: OR = 1.77, 95%CI = 1.46-2.16), followed by cannabis-only use, and tobacco-only use. Compared to tobacco-only use, co-use (OR = 1.35, 95%CI = 1.08-1.69) and cannabis-only use (OR = 1.17, 95%CI = 1.00-1.37) were associated with higher adjusted odds for anxiety, but not for depression. Daily use (vs. non-daily use) of cigarettes, e-cigarettes, and cannabis were associated with higher adjusted odds for anxiety and depression.

conclusionsUse of tobacco and/or cannabis, particularly co-use of both substances, were associated with poor mental health. Integrating mental health support with tobacco and cannabis cessation may address this co-morbidity.

Indexed as

CannabisCitizen ScienceCOVID-19Electronic Nicotine Delivery SystemsHallucinogensAdolescentAdultAnxietyCannabinoid Receptor AgonistsCohort StudiesDepressionFemaleHumansMaleMiddle AgedUnited StatesCannabinoid Receptor AgonistsHallucinogens

Identifiers

PMID37703257
PMCPMC10499225
OpenAlexW4386702962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.