Evidence map›Paper›PMID 37703130›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes.

Alexander Kastner, Hemma Schueffl, Patrick A Yassemipour, Bernhard K Keppler, Petra Heffeter, Christian R Kowol

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes.Angewandte Chemie (International ed. in English) · 2023
    Article
  2. Einbau von (Bioaktiven) Äquatorialen Liganden in Platin(IV)-Komplexe.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexander KastnerUniversity of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090, Vienna, Austria.ORCID 0000-0002-4678-9997
Hemma SchuefflCenter for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.ORCID 0000-0002-9959-9716
Patrick A YassemipourUniversity of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090, Vienna, Austria.
Bernhard K KepplerUniversity of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090, Vienna, Austria.ORCID 0000-0003-0877-1822
Petra HeffeterCenter for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.ORCID 0000-0001-6401-8646
Christian R KowolUniversity of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090, Vienna, Austria.ORCID 0000-0002-8311-1632
University of Vienna · ATComprehensive Cancer Center Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platinum(IV) prodrugs are highly interesting alternatives to platinum(II) anticancer therapeutics due to their increased tumor selectivity and reduced side effects. In contrast to the established theory, we recently observed that the equatorial ligand(s) of e.g. oxaliplatin(IV) complexes can be hydrolyzed with formation of [(DACH)Pt(OH

Indexed as

Antineoplastic AgentsNeoplasmsProdrugsCell Line, TumorHumansLigandsOrganoplatinum CompoundsOxaliplatinPlatinumAntineoplastic AgentsLigandsOrganoplatinum CompoundsOxaliplatinPlatinumProdrugsAntitumor AgentsBioinorganic ChemistryPlatinumSynthesis Design

Identifiers

PMID37703130
PMCPMC10952260
OpenAlexW4386718940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.