Evidence map›Paper›PMID 37703083›Full record

Trial reportAmerican journal of respiratory and critical care medicine2023

Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Trial.

Paul McNally, Karen Lester, Gavin Stone, Basil Elnazir, Michael Williamson, Des Cox, Barry Linnane, Laura Kirwan, David Rea, Paul O'Regan and 6 more

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Multiple breath washout in primary ciliary dyskinesia: a systematic review of the literature.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. mSphere · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Article
  18. Aging Gracefully: Does Elexacaftor/Tezacaftor/Ivacaftor Safety and Efficacy Stand the Test of Time?American journal of respiratory and critical care medicine · 2025
    Article
  19. bioRxiv : the preprint server for biology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Paul McNallyDepartment of Pediatrics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID 0000-0001-7102-1712
Karen LesterDepartment of Pediatrics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Gavin StoneDepartment of Pediatrics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Basil ElnazirChildren's Health Ireland, Dublin, Ireland.
Michael WilliamsonChildren's Health Ireland, Dublin, Ireland.
Des CoxChildren's Health Ireland, Dublin, Ireland.
Barry LinnaneSchool of Medicine, University of Limerick, Limerick, Ireland.
Laura KirwanCystic Fibrosis Registry of Ireland, Dublin, Ireland.
David ReaChildren's Health Ireland, Dublin, Ireland.
Paul O'ReganCystic Fibrosis Registry of Ireland, Dublin, Ireland.
Tom SempleRoyal Brompton Hospital, London, United Kingdom.
Clare SaundersRoyal Brompton Hospital, London, United Kingdom.
Harm A W M TiddensErasmus Medical Centre, Rotterdam, the Netherlands.
Edward McKoneSt. Vincent's University Hospital, Dublin, Ireland; and.ORCID 0000-0002-5455-8208
Jane C DaviesRoyal Brompton Hospital, London, United Kingdom.
RECOVER Study Group
Children's Health Ireland at Crumlin · IERoyal Brompton Hospital · GBCystic Fibrosis Ireland · IEErasmus University Rotterdam · NLSt. Vincent's University Hospital · IEUniversity of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cystic FibrosisAminophenolsBenzodioxolesChloride Channel AgonistsChloridesCystic Fibrosis Transmembrane Conductance RegulatorHumansIndolesLungMutationPyrazolesPyridinesPyrrolidinesQuality of LifeQuinolonesTomography, X-Ray ComputedAminophenolsBenzodioxolesChloride Channel AgonistsChloridesCystic Fibrosis Transmembrane Conductance RegulatorelexacaftorIndolesivacaftorPyrazolesPyridinesPyrrolidinesQuinolonestezacaftorcomputed tomographycystic fibrosiselexacaftor/tezacaftor/ivacaftorlung clearance indexsweat chloride

Identifiers

PMID37703083
OpenAlexW4386704552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.