Evidence map›Paper›PMID 37702922›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023

Pythium insidiosum: insights into biofilm formation and antibiofilm activity of antifungal drugs.

B Pippi, E S Loreto, S Merkel, A R Joaquim, M E Krummenauer, P Reginatto, M H Vainstein, S F Andrade, A M Fuentefria, J M Santurio and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

B PippiGraduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
E S LoretoSobresp Faculty of Health Sciences, Santa Maria, RS, Brazil.ORCID http://orcid.org/0000-0003-0408-5294
S MerkelGraduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0002-9796-2980
A R JoaquimGraduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-9322-7794
M E KrummenauerBiotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0003-2371-296X
P ReginattoGraduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-6754-2061
M H VainsteinBiotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-3914-2300
S F AndradeGraduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0003-2873-7939
A M FuentefriaGraduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0003-2979-4417
J M SanturioGraduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID http://orcid.org/0000-0001-6286-9076
R A ZanetteGraduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil. regnitro@yahoo.com.br.ORCID http://orcid.org/0000-0003-4432-2231
Universidade Federal do Rio Grande do Sul · BRUniversidade Federal de Santa Maria · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigate the ability of Pythium insidiosum to form biofilms across various substrates and the antibiofilm efficacy of 8-hydroxyquinoline derivatives (8-HQs). Biofilms of P. insidiosum were cultured on polystyrene plates, contact lenses, and horsehair. We provide the first evidence of P. insidiosum's biofilm-forming capability, thus considerably expanding our understanding of its transmission and pathogenesis. Our results demonstrate that 8-HQs effectively inhibit biofilm formation and eradicate pre-existing biofilms, underscoring their potential as a novel treatment strategy for pythiosis, a disease currently lacking a gold-standard treatment. This finding has particular relevance for ocular pythiosis associated with contact lens usage and potential infection sources in animals. Our results contribute to the scientific knowledge base and directly impact innovative therapeutic interventions' development.

Indexed as

PythiosisPythiumAnimalsAntifungal AgentsAntifungal Agents8-HydroxyquinolineAntimicrobial resistanceBiofilm formationClioquinolPythium insidiosum

Identifiers

PMID37702922
PMCPMC10689302
OpenAlexW4386704038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.