Evidence map›Paper›PMID 37702903›Full record

ArticleAnnals of surgical oncology2023

Current Practices in Hepatic Artery Infusion (HAI) Chemotherapy: An International Survey of the HAI Consortium Research Network.

Sean J Judge, Tara Ghalambor, Michael J Cavnar, Michael E Lidsky, Ryan P Merkow, May Cho, Ismael Dominguez-Rosado, Paul J Karanicolas, Skye C Mayo, Flavio G Rocha and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sean J JudgeDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tara GhalamborDepartment of Surgery, University of California, Davis, Sacramento, CA, USA.
Michael J CavnarDepartment of Surgery, University of Kentucky College of Medicine, Lexington, KY, USA.
Michael E LidskyDepartment of Surgery, Duke University School of Medicine, Durham, NC, USA.
Ryan P MerkowDepartment of Surgery, Northwestern University, Chicago, IL, USA.
May ChoDepartment of Medicine, University of California Irvine, Orange, CA, USA.
Ismael Dominguez-RosadoDepartment of Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico City, Mexico.
Paul J KaranicolasDepartment of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Skye C MayoDivision of Surgical Oncology, Department of Surgery, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Flavio G RochaDivision of Surgical Oncology, Department of Surgery, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Ryan C FieldsDivision of Surgical Oncology, Department of Surgery, Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Reema A PatelDepartment of Medical Oncology, University of Kentucky College of Medicine, Lexington, KY, USA.
Hagen F KenneckeGI Oncology, Providence Health Cancer Institute, Portland, OR, USA.
Bas Groot KoerkampDepartment of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Adam C YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Henrik PetrowskyDepartment of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Devalingham MahalingamDepartment of Medicine, Northwestern University, Chicago, IL, USA.
Nancy KemenyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael D'AngelicaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sepideh GholamiDepartment of Surgery, Northwell Health Cancer Institute, New Hyde Park, NY, USA. sgholami@northwell.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundAn increasing number of hepatic artery infusion (HAI) programs have been established worldwide. Practice patterns for this complex therapy across these programs have not been reported. This survey aimed to identify current practice patterns in HAI therapy with the long-term goal of defining best practices and performing prospective studies.

methodsUsing SurveyMonkey

resultsThirty-six (72%) HCRN members responded to the survey. The most common intended initial indications for HAI at new programs were unresectable colorectal liver metastases (uCRLM; 100%) and unresectable intrahepatic cholangiocarcinoma (uIHC; 56%). Practice patterns evolved such that uCRLM (94%) and adjuvant therapy for CRLM (adjCRLM; 72%) have become the most common current indications for HAI at established centers. Referral patterns for pump placement differed between uCRLM and uIHC, with most patients referred while receiving second- and first-line therapy, respectively, with physicians preferring to evaluate patients for HAI while receiving first-line therapy for CRLM. Concern for extrahepatic disease was ranked as the most important factor when considering a patient for HAI.

conclusionsIndication and patient selection factors for HAI therapy are relatively uniform across most HCRN centers. The increasing use of adjuvant HAI therapy and overall consistency of practice patterns among HCRN centers provides a robust environment for prospective data collection and randomized clinical trials.

Indexed as

Hepatic ArteryInfusions, Intra-ArterialLiver NeoplasmsPractice Patterns, Physicians'Antineoplastic Combined Chemotherapy ProtocolsBile Duct NeoplasmsCholangiocarcinomaColorectal NeoplasmsHumansPrognosisProspective StudiesSurveys and QuestionnairesCholangiocarcinomaColorectal liver metastases (CRLM)Hepatic artery infusionPumpRegional therapy

Identifiers

PMID37702903
PMCPMC11108096

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.