SynthesisEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2023
Self-assembling peptides for managing white spot lesions: a systematic review and meta-analysis.
Synthesis in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- The Effects of Nanohydroxyapatite with and without Low-Power Laser and Cold Atmospheric Plasma on Enamel Remineralization:Journal of dentistry (Shiraz, Iran) · 2025Article
- Article
- Assessment of two novel methods for detecting non-cavitated, smooth surface enamel lesions: an in vitro study.BMC oral health · 2025Article
- Color Masking Ability of Guided Enamel Regeneration with a Novel Self-Assembling Peptide and Resin Infiltration on Artificial Enamel Lesions Under Various Challenges: An In Vitro Spectrophotometric Analysis.Biomimetics (Basel, Switzerland) · 2024Article
- Caries and white spot lesion trajectories of orthodontic patients across an observation period of 20 years.Clinical oral investigations · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe primary objective of the review was to assess the effectiveness of self-assembling P11-4 peptide (SAP) with or without any fluoride agents (FA) in remineralization of the White spot lesions (WSLs)/incipient carious lesions (ICLs) compared to other enamel remineralizing agents/non-intervention/placebo.
methodsHuman RCTs published during the period from 1st January 2000-30th June 2021 were searched in the electronic bibliographic databases and scanning reference lists of articles from PubMed, Google Scholar, and The Cochrane Central Register of Controlled Trials. The Risk-of-Bias was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) tool for all included studies. The statistical heterogeneity between studies was assessed by the Cochrane Q test and I
resultsFour out of eight included trials were assessed to have "high risk" of bias. Mean difference for Laser fluorescence outcome assessment method (SAP v/s FA) was - 4.89 (95% CI: - 17.35 to 7.57; p = 0. 44; I
conclusionConsidering the results observed from the included trials we are uncertain whether SAP/SAP + FA increases/decreases the remineralizing/regeneration of WSLs/ICLs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.