Evidence map›Paper›PMID 37702594›Full record

ArticleMicrobiology (Reading, England)2023

Characterization of tigurilysin, a novel human CD59-specific cholesterol-dependent cytolysin, reveals a role for host specificity in augmenting toxin activity.

Ifrah Shahi, Sophia A Dongas, Juliana K Ilmain, Victor J Torres, Adam J Ratner

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ifrah ShahiDepartment of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
Sophia A DongasDepartment of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
Juliana K IlmainDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.
Adam J RatnerDepartment of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
New York University · US

Funding

Capsular serotype in group B Streptococcus colonization and diseaseR01AI155476 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RATNER, ADAM JONATHAN · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI155476
6 · The paper itself

Abstract

Cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins, produced by numerous Gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface-associated human CD59 (hCD59) for binding, conferring specificity for human cells. We purified a recombinant version of a putative CDC encoded in the genome of

Indexed as

CytotoxinsHost SpecificityAmino AcidsCD59 AntigensCell Line, TumorCholesterolHumansAmino AcidsCD59 AntigensCD59 protein, humanCholesterolCytotoxinscholesterol-dependent cytolysinhuman CD59pore-forming toxinStreptococcus oralis

Identifiers

PMID37702594
PMCPMC10569062
OpenAlexW4386705542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.