Evidence map›Paper›PMID 37702510›Full record

ArticlemSystems2023

Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice.

Johanna M Holman, Louisa Colucci, Dorien Baudewyns, Joe Balkan, Timothy Hunt, Benjamin Hunt, Marissa Kinney, Lola Holcomb, Allesandra Stratigakis, Grace Chen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Johanna M HolmanSchool of Food and Agriculture, University of Maine , Orono, Maine, USA.
Louisa ColucciDepartment of Biology, Husson University , Bangor, Maine, USA.
Dorien BaudewynsDepartment of Psychology, University of Maine , Orono, Maine, USA.
Joe BalkanDepartment of Chemical and Biological Engineering, Tufts University , Medford, Massachusetts, USA.
Timothy HuntDepartment of Biology, University of Maine , Orono, Maine, USA.
Benjamin HuntDepartment of Biology, University of Maine , Orono, Maine, USA.
Marissa KinneySchool of Food and Agriculture, University of Maine , Orono, Maine, USA.
Lola HolcombGraduate School of Biomedical Sciences and Engineering, University of Maine , Orono, Maine, USA.
Allesandra StratigakisSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University , Johnson City, New York, USA.
Grace ChenDepartment of Internal Medicine, University of Michigan Medical School , Ann Arbor, Michigan, USA.
Peter L MosesDepartments of Neurological Sciences and of Medicine, Larner College of Medicine, University of Vermont , Burlington, Vermont, USA.
Gary M MaweDepartments of Neurological Sciences and of Medicine, Larner College of Medicine, University of Vermont , Burlington, Vermont, USA.
Tao ZhangSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University , Johnson City, New York, USA.
Yanyan LiSchool of Food and Agriculture, University of Maine , Orono, Maine, USA.ORCID 0000-0002-8139-6718
Suzanne L IshaqSchool of Food and Agriculture, University of Maine , Orono, Maine, USA.ORCID 0000-0002-2615-8055
University of Maine · USBinghamton University · USUniversity of Vermont · USHusson University · USTufts University · USUniversity of Michigan · US

Funding

Harnessing gut microbiota to reduce inflammation using broccoli-sprout dietsR15DK133826 · NIDDK · UNIVERSITY OF MAINE ORONO · PI PELLEGRINI, SUZANNE ISHAQ · 2022 to 2022
$436k
NIDDK NIH HHS R15 DK133826
6 · The paper itself

Abstract

importanceEvaluating bacterial communities across different locations in the gut provides a greater insight than fecal samples alone and provides an additional metric by which to evaluate beneficial host-microbe interactions. Here, we show that 10% steamed broccoli sprouts in the diet protects mice from the negative effects of dextran sodium sulfate-induced colitis, that colitis erases biogeographic patterns of bacterial communities in the gut, and that the cecum is not likely to be a significant contributor to colonic bacteria of interest in the DSS mouse model of ulcerative colitis. Mice fed the broccoli sprout diet during colitis performed better than mice fed the control diet while receiving DSS. The identification of accessible dietary components and concentrations that help maintain and correct the gut microbiome may provide universal and equitable approaches to IBD prevention and recovery, and broccoli sprouts represent a promising strategy.

Indexed as

BrassicaColitisGastrointestinal MicrobiomeAnimalsInflammationMiceBacteroides thetaiotaomicronbiogeographybroccoli sproutsdietary bioactivesglucoraphaningut microbiotainflammatory bowel diseasesulforaphaneulcerative colitis

Identifiers

PMID37702510
PMCPMC10654075
OpenAlexW4386704546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.