Evidence map›Paper›PMID 37702397›Full record

ArticleACS nano2023

pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy.

L Palanikumar, Mona Kalmouni, Tatiana Houhou, Osama Abdullah, Liaqat Ali, Renu Pasricha, Rainer Straubinger, Sneha Thomas, Ahmed Jawaad Afzal, Francisco N Barrera and 1 more

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  9. Chlorin Activity Enhancers for Photodynamic Therapy.Molecules (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Article
  12. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
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  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

L PalanikumarBiology Program, Division of Science, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Mona KalmouniBiology Program, Division of Science, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Tatiana HouhouBiology Program, Division of Science, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-4166-6306
Osama AbdullahCore Technology Platforms, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.ORCID 0000-0003-4326-1318
Liaqat AliCore Technology Platforms, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Renu PasrichaCore Technology Platforms, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Rainer StraubingerCore Technology Platforms, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Sneha ThomasCore Technology Platforms, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Ahmed Jawaad AfzalBiology Program, Division of Science, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Francisco N BarreraDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee Knoxville, Knoxville, Tennessee 37996, United States.ORCID 0000-0002-5200-7891
Mazin MagzoubBiology Program, Division of Science, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.ORCID 0000-0003-3414-6617
New York University Abu Dhabi · AEUniversity of Tennessee at Knoxville · US

Funding

Mechanisms of modulation of transmembrane interactionsR35GM140846 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BARRERA, FRANCISCO NICOLAS · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM140846
6 · The paper itself

Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) have gained considerable attention as potential alternatives to conventional cancer treatments. However, these approaches remain limited by low solubility, poor stability, and inefficient targeting of many common photosensitizers (PSs) and photothermal agents (PTAs). To overcome the aforementioned limitations, we engineered biocompatible and biodegradable tumor-targeted upconversion nanospheres with imaging capabilities. The multifunctional nanospheres consist of a sodium yttrium fluoride core doped with lanthanides (ytterbium, erbium, and gadolinium) and the PTA bismuth selenide (NaYF

Indexed as

Multimodal ImagingNanospheresNeoplasmsPhotochemotherapyPhotosensitizing AgentsPhotothermal TherapySilicon DioxideAnimalsChlorophyllidesHumansHydrogen-Ion ConcentrationMiceMice, Inbred BALB CPorosityPorphyrinsChlorophyllidesPhotosensitizing AgentsphytochlorinPorphyrinsSilicon Dioxidecancer therapydiagnostic imagingmesoporous silicanear-infrared lightphotodynamic therapyphotothermal therapyupconversion

Identifiers

PMID37702397
PMCPMC10569106
OpenAlexW4386703978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.