ArticleJournal of the American Heart Association2023
Risk Factors and Outcomes With Progressive Mitral Annular Calcification.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women.Current atherosclerosis reports · 2026Review
- Caseous calcification of the mitral annulus as a rare cause of embolic stroke in a young patient with end-stage renal disease: a case report.European heart journal. Case reports · 2026Article
- Article
- Mitral annular calcification: implications on clinical outcomes and interventions.Annals of cardiothoracic surgery · 2025Review
- Tips and tricks in addressing mitral annular calcification in mitral valve surgery.Annals of cardiothoracic surgery · 2025Review
- Mitral Annular Calcification: Natural History, Prognosis, and Clinical Outcomes.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Mitral annular calcification in interventional cardiology: address all fears.AsiaIntervention · 2025Review
- Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals.Scientific reports · 2025Article
- Review
- Contemporary diagnosis and treatment of valvular heart disease in Korea: a nationwide hospital-based registry study.Journal of cardiovascular imaging · 2024Article
- Rethinking Mitral Annular Calcification and Its Clinical Significance: From Passive Process to Active Pathology.Journal of personalized medicine · 2024Review
- Mitral Annular Calcification-Related Valvular Disease: A Challenging Entity.Journal of clinical medicine · 2024Review
- Clinical and Hemodynamic Implications of Mitral Annular Calcification.Journal of the Heart Valve SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Mitral annular calcification (MAC) is a chronic degenerative process that may progress. This study aimed to investigate associating factors and clinical implications of MAC progression. Methods and Results Among 560 patients with MAC identified by transthoracic echocardiography between January 2012 and June 2016, 138 patients (mean±SD age 72.7±10.2 years, 73 women) with mild or moderate MAC who received follow-up examination within 18 to 36 months were retrospectively analyzed. Progressive MAC was defined as hemodynamic or structural profiles that had worsened by more than 1 grade. Hemodynamic features were assessed by the transmitral mean diastolic pressure gradient (MDPG), and structural features were assessed by the MAC angle in the parasternal short-axis view. The clinical outcome was defined as a composite of all-cause mortality, hospitalization for heart failure, and occurrence of ischemic stroke. Forty-three patients (31.2%) showed progressive MAC. Patients with progressive MAC had higher systolic blood pressure, pulse pressure, MAC angle, and MDPG than those with stable MAC. Patients with progressive MAC had smaller left ventricular (LV) end-systolic dimensions and higher LV ejection fractions compared with those with stable MAC. In multivariate analysis, pulse pressure, LV ejection fraction, MAC angle, and MDPG at baseline were significantly associated with MAC progression. During a median of 39.2 months' follow-up, patients with progressive MAC showed poorer clinical outcomes than those with stable MAC (log-rank
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