Article in Allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
27 authors at 7 institutions in 2 countries.
Georgii BrazhnikovDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2316-8346
Evgenii SmolnikovNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0003-1302-4178
Alla LitovkinaNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0002-5021-9276
Tianchi JiangDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0009-0000-4590-698X
Artem ShatilovNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0002-4675-8074
Inna TulaevaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-5825-2687
Mikhail TulaevDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0009-0003-3338-9606
Alexander KaraulovLaboratory of Immunopathology, Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.ORCID 0000-0002-1930-5424
Alina PoroshinaNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0002-0400-2201
Yury ZhernovF. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.ORCID 0000-0001-8734-5527
Margarete Focke-TejklDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-3433-5071
Milena WeberDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6126-4075
Oluwatoyin AkinfenwaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0911-8860
Olga ElisyutinaNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0002-4609-2591
Sergey AndreevNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0001-8297-579X
Igor ShilovskiyNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0001-5343-4230
Nadezhda ShershakovaNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0001-6444-6499
Valeriy SmirnovNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0002-8232-6682
Elena FedenkoNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0003-3358-5087
Tatiana Sergeevna LepeshkovaDepartment of Polyclinic Pediatrics, Ural State Medical University, Yekaterinburg, Russia.ORCID 0000-0002-0716-3529
Evgeny Cronidovich BeltyukovDepartment of Faculty Therapy, Endocrinology, Allergology and Immunology, Ural State Medical University, Yekaterinburg, Russia.ORCID 0000-0003-2485-2243
Veronika Victorovna NaumovaDepartment of Faculty Therapy, Endocrinology, Allergology and Immunology, Ural State Medical University, Yekaterinburg, Russia.ORCID 0000-0002-3028-2657
Michael KundiInstitute for Hygiene and Applied Immunology, Center for Public Health, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2707-3213
Musa KhaitovNational Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.ORCID 0000-0003-4961-9640
Ursula WiedermannInstitute for Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1302-3223
Rudolf ValentaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5944-3365
Raffaela CampanaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-9309-9908
Medical University of Vienna · ATFederal Medical-Biological Agency · RUSechenov University · RUPeoples' Friendship University of Russia · RUUral State Medical University · RUKarl Landsteiner University of Health Sciences · ATPirogov Russian National Research Medical University · RU
Funding
Austrian Science Fund P34472-BDanube ARC grant of the country of Lower AustriaMegagrant 075-15-2021-632Russian Science Foundation 23-75-30016
6 · The paper itself
Abstract
backgroundThe nature of epitopes on Bet v 1 recognized by natural IgG antibodies of birch pollen allergic patients and birch pollen-exposed but non-sensitized subjects has not been studied in detail.
objectiveTo investigate IgE and IgG recognition of Bet v 1 and to study the effects of natural Bet v 1-specific IgG antibodies on IgE recognition of Bet v 1 and Bet v 1-induced basophil activation.
methodsSera from birch pollen allergic patients (BPA, n = 76), allergic patients without birch pollen allergy (NBPA, n = 40) and non-allergic individuals (NA, n = 48) were tested for IgE, IgG as well as IgG
resultsIgE antibodies from BPA patients react almost exclusively with conformational epitopes whereas IgG, IgG
conclusionIgE and IgG antibodies from BPA patients and birch pollen-exposed non-sensitized subjects recognize different epitopes. These findings explain why natural allergen-specific IgG do not protect against allergic symptoms and suggest that allergen-specific IgE and IgG have different clonal origin.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Natural human Bet v 1-specific IgG antibodies recognize non-conformational epitopes whereas IgE reacts with conformational epitopes. · full record | OpenQuestion