Evidence map›Paper›PMID 37701905›Full record

ArticleLeukemia research reports2023

Isochromosome 7p, i(7)(p10): A rare AML, myelodysplasia-related entity.

Reza Nejati, Ryan Neumann-Domer, Zemin Liu, Lori Koslosky, Erin Neumann-Domer, Jianming Pei, Y Lynn Wang, Joseph R Testa

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Reza NejatiDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Ryan Neumann-DomerDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Zemin LiuDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Lori KosloskyDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Erin Neumann-DomerDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Jianming PeiDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Y Lynn WangDepartment of Pathology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA.
Joseph R TestaClinical Cytogenomics Lab, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Fox Chase Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe genomic findings in an AML case with isochromosome 7p, i(7)(p10), in which SNP array analysis uncovered an additional 7.07-Mb 20q deletion not detected by karyotyping. Several AML cases with i(7)(p10) as an isolated cytogenetic finding have been previously reported. Based on consequent loss of 7q, we propose that AML with i(7)(p10) represents a distinct entity belonging in the WHO group -7/7q-, which represents one of the genetic abnormalities defining AML, myelodysplasia-related. Additionally, the focal del(20q) identified here adds support for a specific common region of deletion in 20q in myeloid malignancies, implicating a small number of candidate genes.

Indexed as

20q deletion7q deletionAcute myeloid leukemiaChromosome microarray analysisi(7p)Mutations

Identifiers

PMID37701905
PMCPMC10493252
OpenAlexW4386257861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.