Evidence map›Paper›PMID 37701451›Full record

ArticleBioactive materials2024

Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts.

Charles M Kerr, Sophia E Silver, Yi Sun Choi, Martha E Floy, Amy D Bradshaw, Seung-Woo Cho, Sean P Palecek, Ying Mei

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Charles M KerrMolecular Cell Biology and Pathobiology, Medical University of South Carolina, Charleston, SC, USA.
Sophia E SilverBioengineering Department, Clemson University, Clemson, SC, USA.
Yi Sun ChoiDepartment of Biotechnology, Yonsei University, Seoul, South Korea.
Martha E FloyDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Amy D BradshawDepartment of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA.
Seung-Woo ChoDepartment of Biotechnology, Yonsei University, Seoul, South Korea.
Sean P PalecekDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Ying MeiBioengineering Department, Clemson University, Clemson, SC, USA.
Medical University of South Carolina · USUniversity of Wisconsin–Madison · USYonsei University · KRClemson University · US

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI LATOUR, ROBERT A · 2012 to 2018
$14.9M
A Multi-Omics Approach to Discover Metabolic Critical Quality Attributes for Cardiomyocyte BiomanufacturingR01HL148059 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PALECEK, SEAN P · 2019 to 2022
$1.5M
Nanowired human cardiac spheroids for heart repairR01HL133308 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2017 to 2020
$1.5M
Nanowired humam cardiac organoid derived exosomes for heart repairR01HL168255 · NHLBI · CLEMSON UNIVERSITY · PI Ying Mei · 2023 to 2026
$1.5M
Nanowired human isogenic cardiac organoids to treat acute myocardial ischemia/reperfusion injuriesU01HL169361 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2023 to 2024
$746k
Human organoid model for COVID-19 myocarditisR21HL167211 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2023 to 2024
$411k
Improving cardiovascular disease modeling using human pluripotent stem cell-derived cardiac fibroblastsF31HL154665 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KERR, CHARLES MATTHEW · 2020 to 2022
$126k
Cellular Mechanisms of Cardiac ECM Structure and FunctionI01BX005943 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI Amy D Bradshaw, Michael R Zile · 2023 to 2026
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BLRD VA I01 BX005943NHLBI NIH HHS F31 HL154665NHLBI NIH HHS R01 HL133308NHLBI NIH HHS R01 HL148059NHLBI NIH HHS R01 HL168255NHLBI NIH HHS R21 HL167211NHLBI NIH HHS U01 HL169361NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

Human induced pluripotent stem cell derived cardiac fibroblasts (hiPSC-CFs) play a critical role in modeling human cardiovascular diseases

Indexed as

Activated fibroblastBiomimetic substrateExtracellular matrixhiPSC-derived cardiac fibroblastsRNA sequencing

Identifiers

PMID37701451
PMCPMC10493503
OpenAlexW4386509130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.