ReviewLe infezioni in medicina2023
Leptospirosis in India: a systematic review and meta-analysis of clinical profile, treatment and outcomes.
Review in Le infezioni in medicina, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Leptospirosis and its co-infections in India: prevalence, geographic distribution, and clinical implications.BMC infectious diseases · 2026Pooled it
- Pooled it
- Multidrug-resistant and virulence traits in genetically distinct vesicular Leptospira inhabiting farmland and sewage in Southern India.Scientific reports · 2026Article
- Article
- Clinico-Epidemiological Profile of Leptospirosis Among Patients Attending a Tertiary Care Center in Rajasthan.Cureus · 2026Article
- Endemicity, Clinical Features, Risk Factors, and the Potential for Severe Infection inTropical medicine and infectious disease · 2025Article
- Emergence of human leptospirosis in Meghalaya, India: Clinical evidence from a hilly non-endemic region.The Indian journal of medical research · 2025Article
- Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience.World journal of clinical cases · 2025Article
- Zoonotic disease outbreaks reported under India'sThe Lancet regional health. Southeast Asia · 2025Article
- Through the Haze of Hemorrhage: Unraveling Leptospirosis With Diffuse Alveolar Hemorrhage.Cureus · 2025Article
- Development of One Health-based community surveillance system to study zoonotic diseases: a study protocol.Frontiers in public health · 2025Article
- Article
- A clinicoepidemiological study of serologically diagnosed acute febrile illness in a teaching hospital, Kolkata.Journal of family medicine and primary care · 2024Article
- Peripartum Infections: A Position Statement of the Indian Society of Critical Care Medicine.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Epidemiological Features of Leptospirosis and Identification ofInfectious disease reports · 2024Article
- Acute Calculous Cholecystitis Associated with Leptospirosis: Which is the Emergency? A Case Report and Literature Review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Leptospirosis in India: insights on circulating serovars, research lacunae and proposed strategies to control through one health approach.One health outlook · 2024Review
- Modeling the dynamics of leptospirosis in India.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Leptospirosis is a zoonotic bacterial infection with significant mortality and morbidity, especially in resource-limited settings. This systematic review aimed to study the clinical profile and outcome of patients with leptospirosis in India. Methodology: All articles up to 02.08.2022 were searched using the two databases, PubMed and Scopus. A total of 542 articles were found using the search terms related to 'leptospirosis' and 'India'. After two rounds of screening, 55 articles were included. The data were collected on epidemiology, clinical features, laboratory features and treatment of patients with leptospirosis. Results: Most cases of leptospirosis were reported from the coastal belt. A large percentage of patients were identified as farmers, and exposure to rainfall was identified as an important risk factor. Fever was present in 97%, and conjunctival suffusion was present in 35% of cases. Haemoptysis, gastrointestinal bleeding, and haematuria were present in 5%, 5% and 12% of patients, respectively. Liver and kidney were involved in 34% and 35% of the patients, respectively. The average haemoglobin, leucocyte count and platelet count across various studies ranged from 9.6-12.5 grams/dl, 8.8-11.3 thousand/μl and 20-130 thousand/μl, respectively. Treatment details were sparsely available in some studies, with penicillin, ceftriaxone, and doxycycline used commonly. The pooled mortality across various studies was calculated as 11% [95% CI-8-15%, I Conclusions: Leptospirosis is associated with significant mortality in Indian settings. There is a need for studies focussing on treatment modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.