Evidence map›Paper›PMID 37701182›Full record

ArticleFrontiers in urology2022

Effects of pharmacological neurotrophin receptor inhibition on bladder function in female mice with cyclophosphamide-induced cystitis.

Harrison W Hsiang, Beatrice M Girard, Lexi Ratkovits, Susan E Campbell, Margaret A Vizzard

Open access · diamondAbstract read
In one paragraph

Article in Frontiers in urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Harrison W HsiangThe Larner College of Medicine, Department of Neurological Sciences, The University of Vermont, Burlington, VT, United States.
Beatrice M GirardThe Larner College of Medicine, Department of Neurological Sciences, The University of Vermont, Burlington, VT, United States.
Lexi RatkovitsThe Larner College of Medicine, Department of Neurological Sciences, The University of Vermont, Burlington, VT, United States.
Susan E CampbellThe Larner College of Medicine, Department of Neurological Sciences, The University of Vermont, Burlington, VT, United States.
Margaret A VizzardThe Larner College of Medicine, Department of Neurological Sciences, The University of Vermont, Burlington, VT, United States.
University of Vermont · US

Funding

Role of proNGF-p75 signaling in the bladder control after spinal cord injuryR01DK120108 · NIDDK · OHIO STATE UNIVERSITY · PI GAO, JIE, VIZZARD, MARGARET ANN · 2019 to 2023
$2.6M
Cystitis-induced bladder dysfunction and painR01DK124580 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2021 to 2024
$2.1M
NIDDK NIH HHS R01 DK120108NIDDK NIH HHS R01 DK124580
6 · The paper itself

Abstract

Interstitial cystitis/bladder pain syndrome is a chronic inflammatory pelvic pain syndrome of unknown etiology characterized by a number of lower urinary tract symptoms, including increased urinary urgency and frequency, bladder discomfort, decreased bladder capacity, and pelvic pain. While its etiology remains unknown, a large body of evidence suggests a role for changes in neurotrophin signaling, particularly that of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Here, we evaluated the effects of pharmacological inhibition of the NGF receptor TrkA, BDNF receptor TrkB, and pan-neurotrophin receptor p75

Indexed as

brain-derived neurotrophic factor (BDNF)cyclophosphamideinterstitial cystitis (IC)/bladder pain syndrome (BPS)nerve growth factorp75TrkATrkBurinary bladder

Identifiers

PMID37701182
PMCPMC10494527
OpenAlexW4308593410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.