ArticleFrontiers in neuroscience2023
Histochemical mapping of the duration of action of photobiomodulation on cytochrome c oxidase in the rat brain.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Transcranial photobiomodulation improves prefrontal oxygenation and impulse control in adults with ADHD: a randomized controlled trial.BMC psychiatry · 2026Trial
- Interhemispheric Metabolic Effects of Transcranial Infrared Laser Stimulation of the Prefrontal Cortex.Human brain mapping · 2026Trial
- Transcranial Photobiomodulation Modulates Oxidative Stress Biomarkers and Complex IV Activity in Anhedonic-Like Behavior.Neurochemical research · 2026Article
- Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration.Drug design, development and therapy · 2026Review
- Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Seizure Frequency and Brain Metabolomics of Rats with Pilocarpine-Induced Seizures.Molecular neurobiology · 2025Article
- Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation.Frontiers in psychiatry · 2025Article
- Photobiomodulation mechanisms: duration of action in the human prefrontal cortex.Frontiers in behavioral neuroscience · 2025Article
- Photobiomodulation increases brain metabolic activity through a combination of 810 and 660 wavelengths: a comparative study in male and female rats.Lasers in medical science · 2024Article
- Prefrontal photobiomodulation produces beneficial mitochondrial and oxygenation effects in older adults with bipolar disorder.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This is the first study mapping the duration of action of Methods: This experiment aimed to map the duration of action of Results: The prefrontal infralimbic cortex showed the earliest significant increase in CCO activity between 1-day post-TILS and sham groups, which continued elevated for 2-4 weeks post-TILS. Significant differences in CCO activity between 2-weeks and sham groups were also found in the lateral septum, accumbens core, CA3 of the hippocampus, and the molecular layer of the hippocampus. The medial amygdala showed a significant decrease in CCO activity between 4-weeks and sham. Further analyses showed significant inter-regional CCO activity correlations among the brain regions as the result of TILS, with the most pronounced changes at 4-weeks post-stimulation. Discussion: The time course of changes in CCO activity and network connectivity suggested that TILS caused different neuroplasticity types of bioenergetic changes at different time scales, depending on brain region and its depth from the cortex. In conclusion, this controlled CCO histochemical study demonstrated a long-lasting duration of action of PBM in the rat brain.
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