Evidence map›Paper›PMID 37700582›Full record

ArticleIndian pediatrics2023

Postoperative Outcomes, and Growth and Brain Injury Outcomes in Spontaneous Intestinal Perforation vs Surgical Necrotizing Enterocolitis in Preterm Infants.

Parvesh Mohan Garg, Katheryn Lett, Md Abu Yusuf Ansari, Isabella Pittman, Robin Riddick, Neha Varshney, Michael Morris, David Sawaya, Charlotte Taylor, Kartik Reddy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Indian pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Clinical utilization of intestinal pathology in the classification of NEC vs SIP cases and prognostication.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Parvesh Mohan GargDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, USA and Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Katheryn LettDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Md Abu Yusuf AnsariDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Isabella PittmanDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Robin RiddickDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Neha VarshneyDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Michael MorrisDepartment of Pediatric Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
David SawayaDepartment of Pediatric Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Charlotte TaylorDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Kartik ReddyDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Peter PorcelliDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
William HillegassDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA and Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
University of Mississippi Medical Center · USJackson Memorial Hospital · USAtrium Health Wake Forest Baptist · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

objectiveTo compare the clinical outcomes in preterm infants following surgical necrotizing enterocolitis (sNEC) and spontaneous intestinal perforation (SIP).

methodsRetro-spective comparison of clinical information in preterm infants with sNEC and SIP admitted between January, 2013 and December 31, 2018. The clinical outcomes were compared in two groups, including postoperative and brain injury detected on brain magnetic resonance imaging (MRI) after clinical and histopathological confirmation of the SIP and the NEC diagnosis.

results114 infants had sNEC, and 37 had SIP. Infants with SIP had lower median gestational age [25.1 weeks (23.5, 27.1) vs 26.6 (24.4, 31.0), P=0.03], an earlier mean (SD) age of disease onset [10.1 (11.3) days vs 19.6 (17.9); P<0.001] and lower maternal chorioamnionitis on placental pathology [4 (23.5%) vs 22 (68.8%); P=0.007), received more often Penrose drain therapy (54% vs 33%; P=0.03), had less median (IQR) bowel length loss [3.3 cm (1.72, 4.38) vs 21.4 (9.55, 35.3); P=<0.001] and had more often intact ileocecal valve (91.4% vs 65.7%; P=0.006] compared to those with sNEC. In addition, those with sNEC had lower median (IQR) weight z scores at the time of discharge [-1.88 (-2.80, -1.09) vs -1.14 (-2.22, -0.44); P=0.036] than SIP. There were no significant differences in postoperative ileus, duration of parenteral nutrition, surgical morbidity, length of stay, mortality, white matter, and grey matter injury on brain MRI at term equivalent age in preterm infants with SIP and sNEC.

conclusionIn our cohort, preterm infants with SIP and sNEC did not show significant differences in postoperative morbidity and brain MRI abnormalities at term equivalent age. sNEC had lower discharge weight z scores. Larger prospective studies are needed for confirmation of these findings.

Indexed as

Brain InjuriesEnterocolitis, NecrotizingInfant, Newborn, DiseasesIntestinal PerforationFemaleHumansInfantInfant, NewbornInfant, PrematurePlacentaPregnancyRetrospective Studies

Identifiers

PMID37700582
PMCPMC10842114
OpenAlexW4386704636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.