ReviewOrphanet journal of rare diseases2023
Gastrointestinal involvement in Klippel-Trénaunay syndrome: pathophysiology, evaluation, and management.
Review in Orphanet journal of rare diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Gastrointestinal Klippel-Trénaunay Syndrome Mimicking Ulcerative Colitis: A Case Report.Case reports in medicine · 2026Article
- Multidisciplinary approach to Klippel-Trenaunay syndrome: a case report.Annals of medicine and surgery (2012) · 2025Article
- Predominant visceral involvement and heterotopic ossification in Klippel-Trenaunay syndrome.Radiology case reports · 2025Article
- Klippel-Trenaunay syndrome in a child presented with bladder hemangioma: a rare manifestation of a rare syndrome.Annals of medicine and surgery (2012) · 2025Article
- Isolated Colorectal Involvement in Klippel-Trenaunay Syndrome: A Case of Extensive Vascular Malformation.International medical case reports journal · 2025Article
- Genitourinary involvement in Klippel-Trénaunay syndrome: pathophysiology, evaluation, and management.Frontiers in surgery · 2025Review
- A Case of Klippel-Trenaunay Syndrome With Gastrointestinal Hemorrhage and Splenomegaly.Cureus · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klippel-Trénaunay syndrome is typically a complex combined capillary-lymphatic-venous malformation in lower limb. Gastrointestinal involvement is not infrequent in Klippel-Trénaunay syndrome. Rectal bleeding is the most common complication. In recent years, this condition has been increasingly reported. However, most authors simply described extreme manifestations or various combinations of clinical observations. The underlying pathophysiology of gastrointestinal involvement in Klippel-Trénaunay syndrome has been underrecognized. Pathophysiologically, some seemingly adequate managements are pitfalls in treatment. Anorectosigmoid vascular malformations in KTS have distinct and more complicated pathophysiologies than anorectal vascular malformation. Once understanding the pathophysiology, some patients can be successfully managed with a staged plan in our practice. Therefore, recognizing the pathophysiologies of gastrointestinal involvement is needed to evaluate, prevent pitfalls, and determine adequate managements for practitioners. Because of the complexity and rarity of this condition, prospective controlled study or a large cohort of patients is impossible. Based on literature review and our practice, we discuss pathophysiologies, evaluation, pitfalls, and treatment strategies for gastrointestinal involvement in Klippel-Trénaunay syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.