Observational studyBMC surgery2023
Prognostic value of APTT combined with fibrinogen and creatinine in predicting 28-Day mortality in patients with septic shock caused by acute enteric perforation.
Observational study in BMC surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The association between coagulation function and prognosis in patients with sepsis: a meta-analysis of predictive performance introduction.Frontiers in medicine · 2025Pooled it
- The Associations Between Fibrinogen and Septic Shock in Critically Ill Patients With Sepsis: A Retrospective Cohort Study.Emergency medicine international · 2026Article
- Nomograms to predict outcome for patients undergoing venoarterial extracorporeal membrane oxygenation treatment for septic shock.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Clinical value of combined detection of procalcitonin, D-dimer and fibrinogen in the evaluation of children with sepsis.Pakistan journal of medical sciences · 2025Article
- The value of NT-proBNP, NLR, Ang-1 combined with APACHE II and SOFA scores in evaluating 28-day mortality of septic shock.Medicine · 2025Observational
- Constructing an early warning model for elderly sepsis patients based on machine learning.Scientific reports · 2025Article
- Comparison between XGboost model and logistic regression model for predicting sepsis after extremely severe burns.The Journal of international medical research · 2024Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic shock is one of the leading causes of mortality in intensive care units. This retrospective study was carried out to evaluate the association of clinical available factors with 28-day mortality. PATIENTS AND
methodIn this observational study, patients with perioperative septic shocks secondary to intra-abdominal infection caused by enteric perforation were included. A total of 328 sepsis patients were admitted to the surgical intensive care units from January 2012 to December 2016. A total of 138 patients met the enrolment criteria and were included in the study. The data of demographic, clinical and laboratory were all recorded.
resultAll these 138 patients received abdominal surgery prior to surgical intensive care units caused by acute enteric perforation. These patients were all met the diagnostic criteria of septic shock according to Sepsis-3. Statistical analysis showed that lactic acid, blood platelet, fibrinogen, creatinine and activated partial thromboplastin time were found to be associated with 28-day mortality. A combination of serum activated partial thromboplastin time combined with fibrinogen and creatinine could predict in-hospital 28-day mortality. The area under the curve of serum activated partial thromboplastin time combined with fibrinogen and creatinine is 0.875 (0.806-0.944).
conclusionIn conclusion, this pilot study demonstrated that these factors can predict the prognosis of septic shock caused by enteric perforation. In order to reduce the mortality, surgeons and intensive care units physician may consider these data in perioperative period.
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