Evidence map›Paper›PMID 37700172›Full record

ArticleAnnals of surgical oncology2023

Nipple-Sparing Mastectomies in Patients over the Age of 60 Years: Factors Associated with Surgical Outcomes.

Nisha Parmeshwar, Catherine L Dugan, Laura L Barnes, Justin K Cheng, Anne K Patterson, Amanda Miller, Rita Mukhtar, Merisa Piper

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nisha ParmeshwarDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA. Nisha.parmeshwar@ucsf.edu.ORCID http://orcid.org/0000-0003-1768-0017
Catherine L DuganDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Laura L BarnesDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Justin K ChengDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Anne K PattersonDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Amanda MillerDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Rita MukhtarDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Merisa PiperDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNipple-sparing mastectomy (NSM) outcomes in the elderly have not been well characterized. The goal of this study was to evaluate NSM outcomes in patients over age 60. PATIENTS AND

methodsA single-institution retrospective cohort study was performed for NSM patients over the age of 60 from January 2004 to January 2022. Demographic, intraoperative, and postoperative variables were collected.

resultsWe identified 136 women who underwent a total of 200 NSMs at a mean age 65.2 years and with mean body mass index of 25. Most (56%) had invasive breast cancer, requiring neoadjuvant chemotherapy in 15%, and 17.5% had radiation prior to NSM. A total of 91% had immediate tissue expander placement. The infection rate was 19%, with 11.5% requiring expander explantation in the follow-up period. In binomial logistic regression analysis, prior radiation increased the odds of any complication by 2.9 (OR 2.93, CI 1.30-6.58, p = 0.009) and increased the odds of infection by 5.7 (OR 5.70, CI 1.95-16.66, p = 0.001), but no associations were seen for other covariates including age, comorbidities, prior chemotherapy, or presence of invasive disease. Diabetes increased the odds of wound breakdown specifically by 9.0 (OR 8.97, CI 2.01-39.92, p = 0.004). Local recurrence was 3% in mean 3.4-year follow-up.

conclusionsOur data support NSM in patients over the age of 60 years with acceptable outcomes within the standard of care. Locoregional recurrence was within the cited range of 0-5%, and only diabetes and prior radiation were associated with reconstructive complications. NSM should thus be offered when appropriate regardless of increased age to achieve oncologic and reconstructive goals.

Indexed as

Breast NeoplasmsDiabetes MellitusMammaplastyAgedFemaleFollow-Up StudiesHumansMastectomyMiddle AgedNeoplasm Recurrence, LocalNipplesRetrospective StudiesTreatment Outcome

Identifiers

PMID37700172
OpenAlexW4386631976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.