Evidence map›Paper›PMID 37700157›Full record

ArticleHuman cell2023

Specific downregulation of microRNA-186 induces neural stem cell self-renewal by upregulating Bmi-1/FoxG1 expression.

Tuantuan Chen, Jing Liu, Yang Liu, Yang Chen, Xue Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tuantuan ChenDepartment of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, 27 Taishun Street, Tiefeng District, Qiqihar City, 161000, Heilongjiang Province, China. 799561151@qmu.edu.cn.
Jing LiuDepartment of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, 27 Taishun Street, Tiefeng District, Qiqihar City, 161000, Heilongjiang Province, China.
Yang LiuDepartment of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, 27 Taishun Street, Tiefeng District, Qiqihar City, 161000, Heilongjiang Province, China.
Yang ChenDepartment of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, 27 Taishun Street, Tiefeng District, Qiqihar City, 161000, Heilongjiang Province, China.
Xue WangDepartment of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, 27 Taishun Street, Tiefeng District, Qiqihar City, 161000, Heilongjiang Province, China.
Qiqihar Medical University · CN

Funding

Basic Research Funding for Higher Education Institutions in Heilongjiang Province 2022-KYYWF-0786
6 · The paper itself

Abstract

Self-renewal and differentiation in neural stem cells (NSCs) are modulated by microRNAs (miRNAs). However, the recent evidence available is not enough to elucidate the role of miRNA in the self-renewal and differentiation of NSCs from developing brain. In this study, we isolated primary NSCs from the forebrain of fetal rat for in vitro analysis. Downregulation of miRNA-186 in response to a specific miRNA inhibitor resulted in upregulation of Bmi-1 and FoxG1, while maintaining NCS self-renewal. Bmi-1 overexpression restored the maintenance of NSCs in vitro. FoxG1 was found to promote the methylation of Foxo3 promoter and inhibited Foxo3 expression. miR-186 upregulation increased the expression of Foxo3 and inhibited NSC self-renewal in the absence of Foxo3. Therefore, we propose that downregulation of miR-186 maintained NSC self-renewal in the postnatal brain by upregulating the Bmi1/FoxG1 expression via FoxO3 elevation.

Indexed as

Cell Self RenewalDown-RegulationForkhead Transcription FactorsGene ExpressionMicroRNAsNerve Tissue ProteinsNeural Stem CellsPolycomb Repressive Complex 1Up-RegulationAnimalsCell DifferentiationCells, CulturedForkhead Box Protein O3ProsencephalonRatsForkhead Box Protein O3Forkhead Transcription FactorsFOXO3 protein, ratMicroRNAsNerve Tissue ProteinsPolycomb Repressive Complex 1Bmi-1FoxG1Foxo3MicroRNA-186Neural stem cells

Identifiers

PMID37700157
OpenAlexW4386631912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.