Evidence map›Paper›PMID 37700024›Full record

ReviewNature reviews. Microbiology2024

The oral microbiome: diversity, biogeography and human health.

Jonathon L Baker, Jessica L Mark Welch, Kathryn M Kauffman, Jeffrey S McLean, Xuesong He

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 441 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
441citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

441 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Assessing the Impact ofNutrients · 2026
    Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Metagenomic analysis of oral microbiota in Chinese children with obesity.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  12. Article
  13. Microbiology spectrum · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

381 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathon L BakerOregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0001-5378-322X
Jessica L Mark WelchThe Forsyth Institute, Cambridge, MA, USA.
Kathryn M KauffmanUniversity at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-1997-947X
Jeffrey S McLeanUniversity of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9934-5137
Xuesong HeThe Forsyth Institute, Cambridge, MA, USA. xhe@forsyth.org.ORCID http://orcid.org/0000-0002-3333-9188

Funding

Spatial Organization of the Oral MicrobiomeR01DE022586 · NIDCR · MARINE BIOLOGICAL LABORATORY · PI Jessica Leigh Mark Welch · 2013 to 2026
$8.7M
Cloud-Based Machine Learning and Biomarker Visual Analytics for Salivary ProteomicsR01DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E, MARK WELCH, JESSICA LEIGH · 2021 to 2025
$6.7M
Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Preventing dental caries through targeted treatment of acid-producing bacteriaR01DE029479 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HE, XUESONG, SUN, JIRUN · 2021 to 2025
$3.7M
Host tRNA-derived small RNAs (tsRNAs) mediate interactions between host and oral microbesR01DE030943 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Xuesong He · 2022 to 2026
$2.4M
Mechanisms underlying the variation in rate and levels of gingival inflammatory responses among the human populationR01DE031470 · NIDCR · UNIVERSITY OF WASHINGTON · PI Jeffrey Scott McLean · 2023 to 2026
$2.2M
Investigating Membrane Alterations as a Mechanism of Acid Tolerance in Cariogenic BacteriaR00DE029228 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI BAKER, JONATHON · 2023 to 2025
$747k
Investigating Membrane Alterations as a Mechanism of Acid Tolerance in Cariogenic BacteriaK99DE029228 · NIDCR · J. CRAIG VENTER INSTITUTE, INC. · PI BAKER, JONATHON · 2020 to 2022
$393k
Uncovering the roles of phages in the ecology of Porphyromonas gingivalis in periodontal diseaseR03DE030987 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KAUFFMAN, KATHRYN M · 2022 to 2023
$321k
NIDCR NIH HHS K99 DE029228NIDCR NIH HHS R00 DE029228NIDCR NIH HHS R01 DE016937NIDCR NIH HHS R01 DE022586NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE029479NIDCR NIH HHS R01 DE030943NIDCR NIH HHS R01 DE031470NIDCR NIH HHS R03 DE030987
6 · The paper itself

Abstract

The human oral microbiota is highly diverse and has a complex ecology, comprising bacteria, microeukaryotes, archaea and viruses. These communities have elaborate and highly structured biogeography that shapes metabolic exchange on a local scale and results from the diverse microenvironments present in the oral cavity. The oral microbiota also interfaces with the immune system of the human host and has an important role in not only the health of the oral cavity but also systemic health. In this Review, we highlight recent advances including novel insights into the biogeography of several oral niches at the species level, as well as the ecological role of candidate phyla radiation bacteria and non-bacterial members of the oral microbiome. In addition, we summarize the relationship between the oral microbiota and the pathology of oral diseases and systemic diseases. Together, these advances move the field towards a more holistic understanding of the oral microbiota and its role in health, which in turn opens the door to the study of novel preventive and therapeutic strategies.

Indexed as

MicrobiotaVirusesArchaeaBacteriaHumansMouth

Identifiers

PMID37700024
PMCPMC11084736

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.