ArticleCommunications medicine2023
Molecular characterization of MRSA collected during national surveillance between 2008 and 2019 in the Netherlands.
Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Brief report: community-associated invasive infection caused by PVL-positive ST1232 (CC398) MRSA in a 15-year-old patient, Poland, 2024.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Clindamycin and daptomycin failure in PVL-positive MRSA infection of the skin and soft tissue.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Article
- Panton-Valentine Leukocidin-Encoding Methicillin-Resistant Staphylococcus aureus, the Netherlands, 2023-2024Emerging infectious diseases · 2026Article
- Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage.The Journal of infectious diseases · 2026Article
- Genomic comparison of methicillin-resistantFrontiers in microbiology · 2026Article
- Genomic characterization of non-CC398 methicillin-resistantFrontiers in public health · 2026Article
- Increasing trend in fusidic acid resistance among MRSA isolates in the Netherlands, 2016-23.JAC-antimicrobial resistance · 2025Article
- Review
- Clonal Complex 398 Methicillin-Resistant Staphylococcus aureus Producing Panton-Valentine Leukocidin, Czech Republic, 2023.Emerging infectious diseases · 2025Article
- Genomic surveillance of multidrug-resistant organisms based on long-read sequencing.Genome medicine · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the Netherlands is a country with a low endemic level, methicillin-resistant Staphylococcus aureus (MRSA) poses a significant health care problem. Therefore, high coverage national MRSA surveillance has been in place since 1989. To monitor possible changes in the type-distribution and emergence of resistance and virulence, MRSA isolates are molecularly characterized.
methodsAll 43,321 isolates from 36,520 persons, collected 2008-2019, were typed by multiple-locus variable number tandem repeats analysis (MLVA) with simultaneous PCR detection of the mecA, mecC and lukF-PV genes, indicative for PVL. Next-generation sequencing data of 4991 isolates from 4798 persons were used for whole genome multi-locus sequence typing (wgMLST) and identification of resistance and virulence genes.
resultsWe show temporal change in the molecular characteristics of the MRSA population with the proportion of PVL-positive isolates increasing from 15% in 2008-2010 to 25% in 2017-2019. In livestock-associated MRSA obtained from humans, PVL-positivity increases to 6% in 2017-2019 with isolates predominantly from regions with few pig farms. wgMLST reveals the presence of 35 genogroups with distinct resistance, virulence gene profiles and specimen origin. Typing shows prolonged persistent MRSA carriage with a mean carriage period of 407 days. There is a clear spatial and a weak temporal relationship between isolates that clustered in wgMLST, indicative for regional spread of MRSA strains.
conclusionsUsing molecular characterization, this exceptionally large study shows genomic changes in the MRSA population at the national level. It reveals waxing and waning of types and genogroups and an increasing proportion of PVL-positive MRSA.
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