Evidence map›Paper›PMID 37700015›Full record

Trial reportSurgical endoscopy2023

Multicenter phase II trial of transanal total mesorectal excision for rectal cancer: preliminary results.

Patricia Sylla, Dana Sands, Alison Ricardo, Antoinette Bonaccorso, Alexandros Polydorides, Mariana Berho, John Marks, Justin Maykel, Karim Alavi, Karen Zaghiyan and 10 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase IIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03144765 (Multicenter Phase II Study of Transanal Total Mesorectal Excision), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03144765 naactive not recruitingnot on this map

Multicenter Phase II Study of Transanal Total Mesorectal Excision (taTME) With Laparoscopic Assistance for Rectal Cancer

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2017 to 2027Enrolled100ConditionsRectal Cancer, SurgeryArmsTransanal Total Mesorectal Excision (taTME)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Short-term outcomes of laparoscopic-assisted transanalWorld journal of gastrointestinal surgery · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 2 countries.

Patricia SyllaDivision of Colon and Rectal Surgery, Mount Sinai Hospital, New York, NY, USA. patricia.sylla@mountsinai.org.ORCID 0000-0001-9737-994X
Dana SandsDepartment of Colon and Rectal Surgery, Cleveland Clinic Florida, Weston, FL, USA.
Alison RicardoDivision of Colon and Rectal Surgery, Mount Sinai Hospital, New York, NY, USA.
Antoinette BonaccorsoDivision of Colon and Rectal Surgery, Mount Sinai Hospital, New York, NY, USA.
Alexandros PolydoridesDepartment of Pathology, Mount Sinai Hospital, New York, NY, USA.
Mariana BerhoExecutive Administration Florida, Cleveland Clinic Florida, Weston, FL, USA.
John MarksDepartment of Colorectal Surgery, Lankenau Medical Center, Wynnewood, PA, USA.
Justin MaykelDivision of Colon and Rectal Surgery, UMass Memorial Medical Center, Worcester, MA, USA.
Karim AlaviDivision of Colon and Rectal Surgery, UMass Memorial Medical Center, Worcester, MA, USA.
Karen ZaghiyanDivision of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mark WhitefordGastrointestinal and Minimally Invasive Surgical Division, The Oregon Clinic, Providence Cancer Center, Portland, OR, USA.
Elisabeth MclemoreDivision of Colorectal Surgery, Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.
Sami ChadiDivision of Surgical Oncology, Department of Surgery, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada.
Sherief F ShawkiDepartment of Colorectal Surgery, Mayo Clinic, Rochester, MN, USA.
Scott SteeleDepartment of Surgery, Cleveland Clinic, Cleveland, OH, USA.
Alessio PigazziDivision of Colorectal Surgery, Department of Surgery, New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
Matthew AlbertDepartment of Colon and Rectal Surgery, Advent Health Orlando, Orlando, FL, USA.
Teresa DeBeche-AdamsDepartment of Colon and Rectal Surgery, Advent Health Orlando, Orlando, FL, USA.
Erin MoshierDepartment of Population Health Sciences and Policy, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Steven D WexnerDepartment of Colorectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Mount Sinai Hospital · USCleveland Clinic Florida · USAdventHealth Orlando · USUMass Memorial Health Care · USCedars-Sinai Medical Center · USCleveland Clinic · USKaiser Permanente · USLankenau Medical Center · USMayo Clinic · USMount Sinai Hospital · USOregon Clinic · USPenn Presbyterian Medical Center · USUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransanal TME (taTME) combines abdominal and transanal dissection to facilitate sphincter preservation in patients with low rectal tumors. Few phase II/III trials report long-term oncologic and functional results. We report early results from a North American prospective multicenter phase II trial of taTME (NCT03144765).

methods100 patients with stage I-III rectal adenocarcinoma located ≤ 10 cm from the anal verge (AV) were enrolled across 11 centers. Primary and secondary endpoints were TME quality, pathologic outcomes, 30-day and 90-day outcomes, and stoma closure rate. Univariable regression analysis was performed to assess risk factors for incomplete TME and anastomotic complications.

resultsBetween September 2017 and April 2022, 70 males and 30 females with median age of 58 (IQR 49-62) years and BMI 27.8 (IQR 23.9-31.8) kg/m

conclusionWhen performed at expert centers, 2-team taTME in patients with low rectal tumors is safe with low conversion rates and high stoma closure rate. Mid-term results will further evaluate oncologic and functional outcomes.

Indexed as

LaparoscopyProctectomyRectal NeoplasmsTransanal Endoscopic SurgeryFemaleHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesRectumTreatment OutcomeAnastomotic complicationCircumferential radial marginConversionRectal cancerStoma-free rateTME gradeTransanal total mesorectal excision

Identifiers

PMID37700015
PMCPMC10709232
OpenAlexW4386631811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.