Evidence map›Paper›PMID 37699967›Full record

ArticleScientific reports2023

Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart.

Francesca Del Gaudio, Dongli Liu, Maarja Andaloussi Mäe, Eike-Benjamin Braune, Emil M Hansson, Qing-Dong Wang, Christer Betsholtz, Urban Lendahl

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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  5. Acyl-CoA-binding protein as a driver of pathological aging.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Francesca Del Gaudio *Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. francesca.del.gaudio@ki.se.ORCID http://orcid.org/0000-0001-8342-1377
Dongli Liu *Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Maarja Andaloussi MäeDepartment of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Eike-Benjamin BrauneDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Emil M HanssonDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Qing-Dong WangBioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Christer BetsholtzDepartment of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Urban LendahlDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. urban.lendahl@ki.se.ORCID http://orcid.org/0000-0001-9543-8141
Karolinska Institutet · SEUppsala University · SEAstraZeneca (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3-deficiency causes vascular smooth muscle cell (VSMC) loss in the vasculature but the consequences for the heart remain largely elusive. Here, we demonstrate that Notch3

Indexed as

CardiomegalyHypertrophy, Left VentricularAnimalsBecaplerminLipid MetabolismMiceMyocytes, CardiacProto-Oncogene Proteins c-sisReceptor, Notch3BecaplerminNotch3 protein, mouseProto-Oncogene Proteins c-sisReceptor, Notch3

Identifiers

PMID37699967
PMCPMC10497627
OpenAlexW4386686630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.