Evidence map›Paper›PMID 37699906›Full record

ArticleNature communications2023

Alk1 acts in non-endothelial VE-cadherin

Gopal Chovatiya, Kefei Nina Li, Jonathan Li, Sangeeta Ghuwalewala, Tudorita Tumbar

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gopal ChovatiyaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-0993-8877
Kefei Nina LiDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Jonathan LiDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Sangeeta GhuwalewalaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Tudorita TumbarDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. tt252@cornell.edu.ORCID http://orcid.org/0000-0002-2273-1889
Cornell University · US

Funding

Tissue regeneration studies by controlled H3 K4/9/27me3 levels in adult mouse skinR01AR073806 · NIAMS · CORNELL UNIVERSITY · PI JOHN T LIS, Tudorita Tumbar · 2018 to 2026
$3.9M
Defining the heterogeneity of cell lineages in the inter-follicular epidermisR01AR070157 · NIAMS · CORNELL UNIVERSITY · PI Tudorita Tumbar · 2017 to 2026
$3.8M
Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skinR01AR081021 · NIAMS · CORNELL UNIVERSITY · PI Tudorita Tumbar · 2023 to 2026
$1.8M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skinR56AR081021 · NIAMS · CORNELL UNIVERSITY · PI TUMBAR, TUDORITA · 2022 to 2022
$398k
NIAMS NIH HHS R01 AR070157NIAMS NIH HHS R01 AR073806NIAMS NIH HHS R01 AR081021NIAMS NIH HHS R56 AR081021NIH HHS S10 OD018516
6 · The paper itself

Abstract

Vascular endothelial (VE)-cadherin is a well-recognized endothelial cell marker. One of its interacting partners, the TGF-β receptor Alk1, is essential in endothelial cells for adult skin vasculature remodeling during hair homeostasis. Using single-cell transcriptomics, lineage tracing and gene targeting in mice, we characterize the cellular and molecular dynamics of skin VE-cadherin

Indexed as

Endothelial CellsHairActivin Receptors, Type IIAnimalsCadherin 5CadherinsHomeostasisMiceActivin Receptors, Type IIAcvrl1 protein, mouseCadherin 5Cadherins

Identifiers

PMID37699906
PMCPMC10497554
OpenAlexW4386691978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.