Evidence map›Paper›PMID 37699777›Full record

ArticleJournal of pediatric surgery2023

Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.

Barrie S Rich, Bryan J Dicken, Deborah F Billmire, Brent R Weil, Jonathan Ross, Negar Fallahazad, Mark Krailo, Furqan Shaikh, A Lindsay Frazier, Florette K Hazard and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 3 countries.

Barrie S RichDivision of Pediatric Surgery, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY, USA. Electronic address: brich@northwell.edu.
Bryan J DickenDivision of Pediatric Surgery, University of Alberta, Edmonton Canada.
Deborah F BillmireDivision of Pediatric Surgery, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
Brent R WeilDivision of Pediatric Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jonathan RossDepartment of Urology, Department of Pediatrics, Rush Medical College, Chicago, IL, USA.
Negar FallahazadChildren's Oncology Group, Public Health Institute, Monrovia, CA, USA.
Mark KrailoChildren's Oncology Group, Public Health Institute, Monrovia, CA, USA; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Furqan ShaikhDivision of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
A Lindsay FrazierDana-Farber/Boston Children's Cancer and Blood Disorders Center Harvard Medical School, Boston, MA, USA.
Florette K HazardDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Michelle M NuñoChildren's Oncology Group, Public Health Institute, Monrovia, CA, USA; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USBoston Children's Hospital · USChildren's Oncology Group · CHCohen Children's Medical Center · USHarvard University · USRiley Hospital for Children · USRush University Medical Center · USStanford University · USUniversity of Alberta · CAUniversity of Toronto · CA

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

backgroundLymphovascular invasion (LVI) has been identified as a poor prognostic factor for a variety of tumors; however, its significance in malignant ovarian germ cell tumors (MOGCT) in pediatric and adolescent patients is not well described. We aim to clarify the significance of LVI in the subset of patients with nongerminomatous MOGCT.

methodsRecords of patients 0-20 years of age with MOGCT enrolled on Children's Oncology Group study AGCT0132 were reviewed. Patients with documented presence or absence of LVI in either institutional or central review pathology reports were included.

resultsOf 130 patients with MOGCTs, 83 patients had of the presence or absence of LVI documented in their pathology report. 42/83 patients (50.6%) were found to have LVI present. The estimated odds of having LVI was higher in patients with stage II and III disease, 11 years and older and with the presence of choriocarcinoma. Event-free survival (EFS) and overall survival (OS) remained high in patients with LVI. Approximately 50% of patients with a documented LVI status in either institutional pathology report or central review were found to have LVI.

conclusionsThe presence of LVI was higher in tumors with adverse risk factors including higher stage and age greater than 11 years. While LVI was not associated with EFS or OS in the intermediate risk group, further work is necessary to determine the effect of LVI on long-term disease-free survival. We, therefore, recommend routinely incorporating LVI status into institutional pathology reports for pediatric and adolescent patients with MOGCT. LEVEL OF EVIDENCE: III.

Indexed as

Neoplasms, Germ Cell and EmbryonalOvarian NeoplasmsAdolescentChildDisease-Free SurvivalFemaleHumansNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesLymphovascular invasionMalignant ovarian germ cell tumorPediatric and adolescent

Identifiers

PMID37699777
PMCPMC10872999
OpenAlexW4386056764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.