Evidence map›Paper›PMID 37699554›Full record

ArticleBiochemistry2023

Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in

Korbin H J West, Stella V Ma, Daniel A Pensinger, Trisha Tucholski, Timothy N Tiambeng, Emma L Eisenbraun, Avishag Yehuda, Zvi Hayouka, Ying Ge, John-Demian Sauer and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. EngineeredBiochemistry · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Synthetic Peptides Capable of Potent MultigroupJournal of the American Chemical Society · 2024
    Article
  8. Signals behindGut microbes
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Korbin H J WestDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.ORCID 0000-0002-4209-3650
Stella V MaDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.
Daniel A PensingerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, 1550 Linden Dr., Madison, Wisconsin 53706, United States.
Trisha TucholskiDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.
Timothy N TiambengDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.ORCID 0000-0002-5132-0501
Emma L EisenbraunDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.
Avishag YehudaInstitute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Zvi HayoukaInstitute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Ying GeDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.ORCID 0000-0001-5211-6812
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, 1550 Linden Dr., Madison, Wisconsin 53706, United States.ORCID 0000-0001-9367-794X
Helen E BlackwellDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States.ORCID 0000-0003-4261-8194
University of Wisconsin–Madison · USHebrew University of Jerusalem · IL

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic SurvivalR01AI137070 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2018 to 2022
$2.9M
Ultra High Resolution Mass Spectrometer for Biomedical ResearchS10OD018475 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GE, YING · 2015 to 2015
$2.0M
MASH Explorer, a Comprehensive Software Environment for Top-Down ProteomicsR01GM125085 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GE, YING · 2018 to 2021
$1.2M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIAID NIH HHS R01 AI137070NIGMS NIH HHS R01 GM125085NIGMS NIH HHS T32 GM008505NIH HHS S10 OD018475NIH HHS S10 OD020022
6 · The paper itself

Abstract

Bacteria can use chemical signals to assess their local population density in a process called quorum sensing (QS). Many of these bacteria are common pathogens, including Gram-positive bacteria that utilize

Indexed as

Listeria monocytogenesQuorum SensingBacterial ProteinsBiofilmsPeptidesStaphylococcus aureusBacterial ProteinsPeptides

Identifiers

PMID37699554
PMCPMC10676741
OpenAlexW4386630203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.