ArticleNature2023
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 55 citations in OpenAlex.
- Safety and Immunogenicity of an Adjuvanted Clostridioides difficile Vaccine Candidate in Healthy Adults: A Randomized Placebo-Controlled Phase 1 Study.The Journal of infectious diseases · 2025Trial
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- Integrating machine learning and WGCNA to identify core candidate genes and decipher immune-related molecular networks in TcdA/TcdB-associated CDI.Antonie van Leeuwenhoek · 2026Article
- CSPG4 Mediates Inflammatory, Cell Death, and Senescence Responses in Enteric Glia Exposed to Clostridioides difficile Toxins.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
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- An integrative multi-omics approach identifies microbiome alterations linked to pathological and behavioral features in autism spectrum disorder.Cell reports. Medicine · 2026Article
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration.Bone research · 2026Article
- Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways.NPJ science of food · 2026Article
- Brain-Region-Mediated Neuroimmune Modulation in Sepsis: Research Advances and Therapeutic Prospects.Journal of inflammation research · 2026Review
- CGRP at the Neuroimmune Interface: Regulator of Host Defense, Tumor Immunity, and Tissue Homeostasis.Research (Washington, D.C.) · 2026Review
- Neuro-immune-bone axis in post-traumatic bone regeneration: temporal regulation, dysregulation mechanisms, and therapeutic implications.Frontiers in immunology · 2026Review
- The swine IsoLoop model of the gut host-microbiota interface enables intra-animal treatment comparisons to advance 3R principles.Gut microbes · 2025Article
- CD44 is a macrophage receptor for TcdB fromGut microbes · 2025Article
- Neuroimmune interactions in health and disease.Nature immunology · 2025Article
- Moderate altitude exposure impacts extensive host-microbiota multi-kingdom connectivity with serum metabolome and fasting blood glucose.Virulence · 2025Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 3 countries.
John Manion *Department of Urology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-2716-3833
Melissa A Musser *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Gavin A KuzielDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Min LiuDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Amy ShepherdDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Siyu WangDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Pyung-Gang LeeDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Leo ZhaoDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Jie ZhangDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Ravi K R MarreddyCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA.
Jeffrey D GoldsmithDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.
Ke YuanDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Julian G HurdleCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA.
Ralf GerhardInstitute of Toxicology, Hannover Medical School, Hannover, Germany.
Rongsheng JinDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-0348-7363
Seth Rakoff-NahoumDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3233-0675
Meenakshi RaoDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. meenakshi.rao@childrens.harvard.edu.ORCID 0000-0002-8194-9204
Min DongDepartment of Urology, Boston Children's Hospital, Boston, MA, USA. min.dong@childrens.harvard.edu.ORCID 0000-0002-1744-7293
Boston Children's Hospital · USTexas A&M Health Science Center · USMedizinische Hochschule Hannover · DEUniversity of California, Irvine · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MTRAINING IN PEDIATRIC GASTROENTEROLOGY &NUTRITIONT32DK007477 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI Scott B Snapper · 1986 to 2026
$13.3MStructure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4MLong-term effects of botulinum neurotoxins on neuronal viabilityR01NS080833 · NINDS · HARVARD MEDICAL SCHOOL · PI Min Dong · 2013 to 2026
$6.8MProgrammable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiomeR01AI171100 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KHALIL, AHMAD SAMIR, RAKOFF-NAHOUM, SETH · 2022 to 2025
$4.1MDeveloping broad-spectrum therapeutics against C. difficile toxinsR01AI158503 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2025
$3.9MMolecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5MTargeted Delivery of Therapeutics into Motor Neurons for Post-exposure Treatment of BotulismR01NS117626 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2021 to 2025
$3.3MMicrobial reactivation of sex steroids and visceral painR01DK130836 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2022 to 2026
$2.7MPositive Selection as a Host Mechanism to Control the MicrobiomeDP2GM136652 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI RAKOFF-NAHOUM, SETH · 2019 to 2019
$2.7MIsoform- and Sex-Specific Functions of CGRP in Gastrointestinal MotilityR01DK135707 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2023 to 2026
$2.6MNHLBI NIH HHS R01 HL150106NHLBI NIH HHS R01 HL171405NIAID NIH HHS R01 AI132387NIAID NIH HHS R01 AI139087NIAID NIH HHS R01 AI158503NIAID NIH HHS R01 AI171100NICHD NIH HHS P30 HD018655NIDDK NIH HHS K08 DK110532NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK130836NIDDK NIH HHS R01 DK135707NIDDK NIH HHS T32 DK007477NIGMS NIH HHS DP2 GM136652NINDS NIH HHS R01 NS080833NINDS NIH HHS R01 NS117626
Abstract
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated gastrointestinal infections
Indexed as
Bacterial ToxinsClostridioides difficileNeurogenic InflammationNeurons, AfferentPericytesAnimalsBacterial ProteinsCalcitonin Gene-Related PeptideCecumChondroitin Sulfate Proteoglycan 4Clostridium InfectionsFrizzled ReceptorsInflammation MediatorsMiceReceptors, Neurokinin-1Signal TransductionBacterial ProteinsBacterial ToxinsCalcitonin Gene-Related PeptideChondroitin Sulfate Proteoglycan 4Frizzled ReceptorsFzd1 protein, mouseFzd2 protein, mouseFzd7 protein, mouseInflammation MediatorsReceptors, Neurokinin-1Substance PtoxB protein, Clostridium difficile
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.