Evidence map›Paper›PMID 37699382›Full record

ArticleNephron2024

Association between the High-Sensitivity C-Reactive Protein/Albumin Ratio and New-Onset Chronic Kidney Disease in Chinese Individuals.

Zihao Zhang, Peipei Liu, Ling Yang, Naihui Zhao, Wenli Ou, Xiaofu Zhang, Yinggen Zhang, Shuohua Chen, Shouling Wu, Xiuhong Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zihao ZhangSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Peipei LiuSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Ling YangSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Naihui ZhaoSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Wenli OuSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Xiaofu ZhangHebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, China.
Yinggen ZhangDepartment of Nuclear Medicine, Kailuan General Hospital, Tangshan, China.
Shuohua ChenDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Shouling WuDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Xiuhong YangSchool of Public Health, North China University of Science and Technology, Tangshan, China.
North China University of Science and Technology · CNKailuan General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInflammation is associated with development of chronic kidney disease (CKD). However, the association of the high-sensitivity C-reactive protein (hs-CRP)/albumin ratio (CAR) on the risk of CKD in the general population is unknown. This study explored the relationship between the CAR and CKD and the ability of this ratio to predict CKD in the general population.

methodsA total of 47,472 participants in the Kailuan study who met the inclusion criteria in 2010 were selected and grouped using the quartile method. A Cox proportional hazard regression model was used to evaluate the association of the CAR on the risk of CKD. The C-index, net reclassification index (NRI), and overall identification index (IDI) were calculated to evaluate the ability of the CAR to predict CKD.

resultsDuring a follow-up of 378,383 person-years, CKD events occurred in 6,249 study participants (13.16%). The Cox proportional hazard regression model showed that the hazard ratio (95% confidence interval) for CKD events was 1.18 (1.10-1.28) in the Q3 group and 1.42 (1.32-1.53) in the Q4 group when compared with the Q1 group. Compared with the single index, the C-index, NRI, and IDI values were significantly improved when the CAR was added for prediction of risk of CKD.

conclusionsA higher CAR was an independent risk factor for CKD. The ability of the CAR to predict CKD was better than that of hs-CRP or albumin. The CAR provides an important reference index for predicting the risk of CKD.

Indexed as

C-Reactive ProteinRenal Insufficiency, ChronicChinaHumansInflammationRisk FactorsC-Reactive ProteinChronic kidney diseaseHigh-sensitivity C-reactive protein/albumin ratioInflammationPredictive valueRisk factors

Identifiers

PMID37699382
PMCPMC10911139
OpenAlexW4386704102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.