Evidence map›Paper›PMID 37699145›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation.

Kamakshi Bankoti, Wei Wang, Gaurang M Amonkar, Linjie Xiong, Jessica E Shui, Caiqi Zhao, Eric Van, Chimwemwe Mwase, Jin-Ah Park, Hongmei Mou and 5 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kamakshi BankotiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Wei WangDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Gaurang M AmonkarDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Linjie XiongDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Jessica E ShuiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Caiqi ZhaoDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Eric VanDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Chimwemwe MwaseDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Jin-Ah ParkDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Hongmei MouThe Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts; and.ORCID 0000-0002-6624-7757
Yinshan FangColumbia Center for Human Development, Columbia University Irving Medical Center, New York, New York.
Jianwen QueColumbia Center for Human Development, Columbia University Irving Medical Center, New York, New York.
Yan BaiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-8393-3062
Paul H LerouDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Xingbin AiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Harvard University · USColumbia University Irving Medical Center · USMassachusetts General Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Improve Lung Regeneration Through Targeting Tuft Cells Following Viral InfectionR01HL159675 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.4M
Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
Age-related mechanisms of T helper 2 memory in the early lungR01HL154549 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AI, XINGBIN · 2021 to 2024
$2.2M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Cholinergic hyperinnernation in early life regulates long-term airway reactivityK08HL135443 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BAI, YAN · 2017 to 2021
$861k
Modeling the premature airway with neonatal airway basal cellsR21AI156597 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LEROU, PAUL HUBERT · 2021 to 2022
$476k
COVID-19 imprints airway basal cells to impair epithelium regenerationR21AI173494 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI AI, XINGBIN · 2023 to 2024
$473k
Targeting Chronic Senescence to Restore Tissue Homeostasis in Myhre syndromeR21AR080778 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LINDSAY, MARK E, MOU, HONGMEI · 2022 to 2023
$386k
NHLBI NIH HHS K08 HL135443NHLBI NIH HHS R01 HL148152NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL154549NHLBI NIH HHS R01 HL159675NIAID NIH HHS R21 AI156597NIAID NIH HHS R21 AI173494NIAMS NIH HHS R21 AR080778NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether coronavirus disease (COVID-19) affects BSC function is unknown. Here, we derived BSC lines from patients with COVID-19 using tracheal aspirates (TAs) to circumvent the biosafety concerns of live-cell derivation. We show that BSCs derived from the TAs of control patients are

Indexed as

COVID-19Epithelial CellsBronchiCell DifferentiationHumansStem Cellsairway basal cellsCOVID-19epithelial regenerationinflammationmucociliary differentiation

Identifiers

PMID37699145
PMCPMC10768838
OpenAlexW4386648189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.