ArticleRheumatology (Oxford, England)2024
Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis: results from the MYONET registry.
Article in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Anti-OJ Antisynthetase Syndrome with Dermatomyositis-Pattern Skin Lesions and Interstitial Lung Disease.Balkan medical journal · 2026Article
- Quantitative spectral computed tomography biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease: a dual-layer detector computed tomography study.Quantitative imaging in medicine and surgery · 2026Article
- Article
- Regional differences in clinical manifestations of antisynthetase syndrome: a comparison between Asian and European cohorts.Arthritis research & therapy · 2026Article
- Registry of idiopathic inflammatory myopathies (REMAS) from nine Brazilian research centers linked to tertiary care and teaching hospitals.Advances in rheumatology (London, England) · 2026Article
- Unilateral lower limb cellulitis-like edema as an atypical cutaneous manifestation of antisynthetase syndrome: a case report and targeted literature review.Frontiers in medicine · 2026Article
- Dermatomyositis: Prevalence, Clinical Spectrum, Diagnostic Approach, and Management Strategies.Archives of internal medicine research · 2026Article
- Immune Myositis Complicating Follicular Lymphoma: Case Report.Reports (MDPI) · 2025Article
- Immune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies.Muscle & nerve · 2025Article
- Antisynthetase Syndrome Masquerading As Psoriasis and Psoriatic Arthritis: A Case Report.Cureus · 2025Article
- Epidemiology of myositis.Current opinion in rheumatology · 2025Review
- Overlapping clinical features in anti-synthetase syndrome and dermatomyositis: A case series.Journal of the American Academy of Dermatology · 2025Article
- Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry.Arthritis research & therapy · 2025Article
- Anifrolumab in Refractory Dermatomyositis and Antisynthetase Syndrome.Case reports in rheumatology · 2025Article
- Cancer in connective tissue disease.Frontiers in immunology · 2025Review
- A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study.Frontiers in immunology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
28 authors.
Funding
Abstract
objectivesTo compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations and malignancy, between adults with anti-synthetase syndrome (ASyS) and DM.
methodsUsing data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1γ/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V-sign, erythroderma, and/or periorbital rash).
resultsIn total 1054 patients were included (DM, n = 405; ASyS, n = 649). In the ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease and cardiac involvement differentiated ASyS-DMskin from DM (all P < 0.001), whereas higher frequency of any of four DM-type rashes-heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V-sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%)-differentiated DM from ASyS-DMskin (all P < 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both P < 0.001).
conclusionDM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management.
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