Evidence map›Paper›PMID 37698745›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Chemotherapy-related symptoms and exercise adherence in older patients with myeloid neoplasms.

Katarina Wang, William Consagra, Marielle Jensen-Battaglia, Amber Kleckner, Ian R Kleckner, Kah Poh Loh

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04035499 (A Mobile Health Exercise Intervention for Older Patients With Myeloid Neoplasms), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04035499 nacompletednot on this map

A Mobile Health Exercise Intervention for Older Patients With Myeloid Neoplasms

TypeinterventionalSponsorUniversity of RochesterRan2020 to 2021Enrolled25ConditionsInterventionArmsGO-EXCAP Mobile App
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Feasibility and preliminary effects of mhealth supportive care interventions in adults with myeloid neoplasms: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Katarina WangSchool of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
William ConsagraDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.
Marielle Jensen-BattagliaDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
Amber KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Ian R KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Kah Poh LohDivision of Hematology/Oncology, Department of Medicine, James P Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA. kahpoh_loh@urmc.rochester.edu.
University of Maryland, Baltimore · USUniversity of Rochester · USUniversity of Rochester Medical Center · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
A Novel Mobile Health Exercise Intervention for Older Patients with Myeloid NeoplasmsK99CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2019 to 2020
$385k
Epigenetic markers, functional status, and exercise in older adults with myeloid neoplasmsR03AG073985 · NIA · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2022 to 2023
$308k
NCI NIH HHS K07 CA221931NCI NIH HHS K99 CA237744NCI NIH HHS R00 CA237744NCI NIH HHS UG1 CA189961NIA NIH HHS P30 AG028747NIA NIH HHS R03 AG073985
6 · The paper itself

Abstract

purposeExercise may ameliorate treatment-related symptoms, but older adults have lower exercise adherence compared to their younger counterparts due to treatment-related symptoms.

methodsWe recruited older patients with myeloid neoplasms receiving chemotherapy to a pilot study of a mobile health exercise intervention. Participants entered their steps and resistance data into the app daily, and symptom data twice a week, over an 8-12 week period. In this proof-of-concept analysis, we used a linear mixed-effects model to assess the association of symptoms from the previous week with exercise adherence in the current week among older adults with myeloid neoplasms.

resultsMean age was 74.3 (SD = 5.0) years (N = 7). At baseline, patients on average walked 2564 daily steps (SD = 1816), which increased to 2967 (SD = 3448) post-intervention. Patients on average performed 3.5 (SD = 2.6) days of resistance training weekly, with mean duration of 21.5 min (SD = 11.6) and rated perceived exertion of 3.68 (SD = 1.78) on a 0-10 scale. Lower average steps in the current week was associated with greater interference with daily activities from pain (β =  - 203.13, p = 0.05), memory (β =  - 492.29, p = 0.09), numbness (β =  - 353.57, p = 0.07), and sadness (β =  - 403.03, p = 0.09) in the previous week. Similarly, lower average resistance minutes in the current week were associated with greater pain, sadness, and anxiety in the previous week.

conclusionsWe found that greater pain, sadness, and anxiety were associated with lower exercise adherence. Symptom monitoring and management in older adults with myeloid neoplasms receiving chemotherapy can promote exercise adherence and in turn improve symptoms.

trial registrationClinicalTrials.gov Identifier: NCT04035499. Registered 7/29/2019.

Indexed as

NeoplasmsAgedAnxietyExerciseHumansPainPilot ProjectsExercise adherenceMyeloid neoplasmsOlder adultsSymptoms

Identifiers

PMID37698745
PMCPMC10883479
OpenAlexW4386623874

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.