Evidence map›Paper›PMID 37698666›Full record

ArticlePituitary2023

Pituitary metastases: a case series and scoping review.

Kaiyun Yang, Sabrina L Begley, Daniel Lynch, Vincent Ye, Jasleen Saini, Enrique Gutierrez, Jaclyn Vialet, Barbara-Ann Millar, Tatianna Conrad, Normand Laperriere and 4 more

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Pituitary, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  13. A CASE OF HYPONATREMIA DUE TO PITUITARY METASTASIS OF LUNG CANCER.Acta endocrinologica (Bucharest, Romania : 2005)
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Kaiyun YangDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Sabrina L BegleyDepartment of Neurosurgery, Northwell Health, Manhasset, NY, USA.
Daniel LynchDepartment of Neurosurgery, Northwell Health, Manhasset, NY, USA.
Vincent YeDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Jasleen SainiDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Enrique GutierrezDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Jaclyn VialetMedical Library, North Shore University Hospital, Manhasset, NY, USA.
Barbara-Ann MillarDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Tatianna ConradDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Normand LaperriereDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Mark BernsteinDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Gelareh ZadehDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
David B ShultzDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Paul N KongkhamDepartment of Neurosurgery, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada. paul.kongkham@uhn.ca.
University of Toronto · CANorthwell Health · USNorth Shore University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo understand the natural history and optimal treatment strategy for pituitary gland metastasis.

methodsWe performed both a retrospective chart review of patients treated at our institution and a scoping review of the topic.

resultsThe retrospective review identified seven patients with an average age of 59.6 years. Primary histologies included breast cancer (4), melanoma (1), renal cell carcinoma (1), and sarcoma (1). Two patients had anterior pituitary endocrine dysfunction, one of whom was the only patient with visual symptoms. All patients were treated with radiosurgery and two also underwent surgical resection. Overall survival ranged from 6.5 to 117 months. Literature review identified 166 patients from 71 studies. The most common primary cancer was lung (27.7%), followed by breast (18.7%) and renal (14.5%) cancer. 107 presented with endocrine dysfunction, including 41 cases of diabetes insipidus and 55 cases of hypopituitarism. 110 presented with visual compromise. 107 patients received radiotherapy, 96 underwent surgical resection and 44 received systemic chemotherapy/immunotherapy. Surgery was significantly associated with an increased likelihood of vision improvement and a decreased likelihood of endocrine normalization. Radiographic regression predicted visual improvement. Median overall survival was 9.9 months (range: 0.2-96).

conclusionsThis scoping review showed that both radiosurgery and surgical resection have been frequently used to treat pituitary metastases with good response. Vision improvement is more likely to happen following surgical resection, likely at the expense of endocrine dysfunction. Despite treatment and radiographic response, patient survival remains less than a year.

Indexed as

Carcinoma, Renal CellDiabetes InsipidusKidney NeoplasmsPituitary NeoplasmsRadiosurgeryHumansMiddle AgedRetrospective StudiesTreatment OutcomeCase seriesMetastasisPituitaryScoping reviewTreatment

Identifiers

PMID37698666
OpenAlexW4386624638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.