Evidence map›Paper›PMID 37698645›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma.

Marnix Lam, Etienne Garin, Xavier Palard-Novello, Armeen Mahvash, Cheenu Kappadath, Paul Haste, Mark Tann, Ken Herrmann, Francesco Barbato, Brian Geller and 6 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03295006 (A TheraSphere® Advanced Dosimetry Retrospective Global Study Evaluation in Hepatocellular Carcinoma Treatment), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03295006 completednot on this map

A TheraSphere® Advanced Dosimetry Retrospective Global Study Evaluation in Hepatocellular Carcinoma Treatment

TypeobservationalSponsorBoston Scientific CorporationRan2016 to 2020Enrolled209ConditionsHepatocellular CarcinomaArmsTheraSphere
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. A novel approach to radioembolization treatment planning using a hybrid [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Predictive value of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Utility of pre-procedural [European journal of nuclear medicine and molecular imaging · 2025
    Observational
  4. Article
  5. Prediction of [EJNMMI physics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 5 countries.

Marnix LamDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. m.lam@umcutrecht.nl.
Etienne GarinNuclear Medicine Department, Eugene Marquis Center, Rennes, France.
Xavier Palard-NovelloNuclear Medicine Department, Eugene Marquis Center, Rennes, France.
Armeen MahvashDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cheenu KappadathDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Paul HasteDepartment of Clinical Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Mark TannDepartment of Clinical Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Francesco BarbatoDepartment of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Brian GellerDepartment of Radiology, University of Florida, Gainesville, FL, USA.
Niklaus SchaeferDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Alban DenysDepartment of Radiology and Interventional Radiology, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Matthew DreherBoston Scientific Corporation, Marlborough, MA, USA.
Kirk D FowersBoston Scientific Corporation, Marlborough, MA, USA.
Vanessa GatesDepartment of Radiology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Riad SalemDepartment of Radiology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Boston Scientific (United States) · USCentre Eugène Marquis · FRDeutschen Konsortium für Translationale Krebsforschung · DEIndiana University School of MedicineNorthwestern University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Lausanne · CHUniversity of Florida · USUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInvestigate reproducibility of two segmentation methods for multicompartment dosimetry, including normal tissue absorbed dose (NTAD) and tumour absorbed dose (TAD), in hepatocellular carcinoma patients treated with yttrium-90 (

methodsTARGET was a retrospective investigation in 209 patients with < 10 tumours per lobe and at least one tumour ≥ 3 cm ± portal vein thrombosis. Dosimetry was compared using two distinct segmentation methods: anatomic (CT/MRI-based) and count threshold-based on pre-procedural

results

conclusionAnatomic segmentation-based dosimetry, versus

trial registrationNCT03295006.

Indexed as

Carcinoma, HepatocellularEmbolization, TherapeuticLiver NeoplasmsHumansMicrospheresReproducibility of ResultsRetrospective StudiesTechnetium Tc 99m Aggregated AlbuminTomography, Emission-Computed, Single-PhotonYttrium RadioisotopesTechnetium Tc 99m Aggregated AlbuminYttrium RadioisotopesDosimetryHepatocellular carcinomaRadioembolizationYttrium-90

Identifiers

PMID37698645
PMCPMC10684706
OpenAlexW4386624306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.