ArticleApplied microbiology and biotechnology2023
Regulation of cell differentiation to promote pullulan synthesis in Aureobasidium pullulans NG.
Article in Applied microbiology and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Fungal morphotype detection and quantification in microscopic images with TU_MyCo-vision: a user-friendly deep learning object detection tool.Fungal biology and biotechnology · 2026Article
- Mechanisms of ROS-mediated interactions between Bacillus aryabhattai LAD and maize roots to promote plant growth.BMC microbiology · 2024Article
- Potential of Pullulan-Based Polymeric Nanoparticles for Improving Drug Physicochemical Properties and Effectiveness.Polymers · 2024Review
- Hyper-Production of Pullulan by a Novel Fungus ofInternational journal of molecular sciences · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Pullulan is a polymer produced by Aureobasidium spp. The yield of pullulan production can be impacted by the cellular differentiation of Aureobasidium spp., which changes with alterations in the growth environment. To improve pullulan yield, identifying key factors that regulate cellular differentiation is crucial. In this study, the main form of pullulan synthesis in Aureobasidium pullulans NG was through swollen cells (SC). The results showed that citric acid (CA) can regulate the cellular differentiation of Aureobasidium pullulans NG by accumulating higher levels of CA in the cells to maintain growth in SC form and increase pullulan production. The addition of 1.0% CA to Aureobasidium pullulans NG for 96 h resulted in a significant increase in pullulan production, producing 18.32 g/l compared to the control group which produced 10.23 g/l. Our findings suggest that controlling cellular differentiation using CA is a promising approach for enhancing pullulan production in Aureobasidium pullulans. KEY POINTS: • The regulation of cell differentiation in Aureobasidium pullulans NG is demonstrated to be influenced by citric acid. • Intracellular citric acid levels in Aureobasidium pullulans NG have been shown to support the growth of swollen cells. • Citric acid has been found to increase pullulan production in Aureobasidium pullulans NG.
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