Evidence map›Paper›PMID 37698592›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2023

Electroanatomical mapping after cardiac radioablation for treatment of incessant electrical storm: a case report from the RAVENTA trial.

Lena Kaestner, Judit Boda-Heggemann, Hannah Fanslau, Jingyang Xie, Achim Schweikard, Frank A Giordano, Oliver Blanck, Boris Rudic

Registry-linked trialOpen access · hybridAbstract readCase Reports
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03867747 (Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03867747 nacompletednot on this map

Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias (RAVENTA)

TypeinterventionalSponsorUniversity Hospital Schleswig-HolsteinRan2019 to 2024Enrolled20ConditionsVentricular TachycardiaArmsCardiac Radiosurgery
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  3. Review
  4. Patient vulnerability in stereotactic arrhythmia radioablation (STAR): a preliminary ethical appraisal from the STOPSTORM.eu consortium.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lena KaestnerDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany. lena.kaestner@umm.de.ORCID 0000-0002-4696-6332
Judit Boda-HeggemannDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
Hannah FanslauDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
Jingyang XieInstitute for Robotics and Cognitive Systems, University of Luebeck, Luebeck, Germany.
Achim SchweikardInstitute for Robotics and Cognitive Systems, University of Luebeck, Luebeck, Germany.
Frank A GiordanoDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
Oliver BlanckDepartment of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany.
Boris RudicI. Department of Medicine: Cardiology, Angiology, Hemostaseology and Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Heidelberg University · DEUniversity of Lübeck · DEUniversity Hospital Schleswig-Holstein · DE

Funding

Horizon 2020 Framework Programme 945119
6 · The paper itself

Abstract

backgroundElectroanatomical mapping (EAM)-guided stereotactic arrhythmia radioablation (STAR) is a novel noninvasive therapy option for patients with monomorphic ventricular tachycardia (VT) refractory to antiarrhythmic drugs and/or urgent catheter ablation (CA). Data on success rates in an emergency situation such as electrical storm (ES) are rare. We present a case of a patient with an initially very poor life expectancy after extensive myocardial infarction with therapy-resistant ES, not amendable for further antiarrhythmic drug therapy, implantable cardioverter-defibrillator implantation, or repeated CA who was introduced to the radiation oncology department for emergency STAR as a bail-out therapy.

methodsTarget volume definition and transfer from EAM to CT were validated and quality assured with a semi-automatic, dedicated visualization tool (CARDIO-RT). Emergency STAR was performed with 25 Gy in the framework of the RAVENTA study. The VT burden gradually decreased after STAR; however, a second VT morphology occurred, which was successfully treated with EAM-guided CA 12 days after STAR.

resultsThe second EAM-guided CA showed areas of low voltage in the irradiated segments, indicating a precise targeting and early functional response to STAR. The patient remained free of any VT recurrence or any radiation-related toxicities and in good general condition during the recent follow-up of 18 months.

conclusionThe case highlights the possible approach, caveats, difficulties, and prognosis of a patient severely affected by therapy-resistant VT in whom CA could not lead to VT suppression. Further studies of putative mechanisms of STAR in the acute and chronic phase of this novel therapy are warranted.

Indexed as

Catheter AblationTachycardia, VentricularAnti-Arrhythmia AgentsHeartHumansPrognosisTreatment OutcomeAnti-Arrhythmia AgentsCatheter ablationElectrical stormElectroanatomical mappingStereotactic arrhythmia radioablationStructural heart diseaseVentricular tachycardia

Identifiers

PMID37698592
PMCPMC10598131
OpenAlexW4386623972

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.