Evidence map›Paper›PMID 37698514›Full record

ArticlePsychological medicine2023

Cumulative lifetime acute stressor exposure interacts with reward responsiveness to predict longitudinal increases in depression severity in adolescence.

Kreshnik Burani, C J Brush, Grant S Shields, Daniel N Klein, Brady Nelson, George M Slavich, Greg Hajcak

Open access · hybridAbstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  8. Testing a Reward-Processing Model of Negative Urgency in Women With and Without Binge Eating.Clinical psychological science : a journal of the Association for Psychological Science · 2025
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  11. [Research advances in reward positivity and internalizing and externalizing problems in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kreshnik BuraniDepartment of Psychology, Florida State University, Tallahassee, FL, USA.ORCID https://orcid.org/0000-0002-1780-5257
C J BrushDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
Grant S ShieldsDepartment of Psychological Science, University of Arkansas, Fayetteville, AR, USA.
Daniel N KleinDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Brady NelsonDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Greg HajcakDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
Florida State University · USStony Brook University · USUniversity of Arkansas at Fayetteville · USUniversity of California, Los Angeles · US

Funding

Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
Trajectories of Reward Sensitivity and Depression Across AdolescenceR01MH097767 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI NELSON, BRADY D · 2012 to 2022
$6.0M
Predoctoral Training Program in Behavioral Brain ResearchT32GM081760 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FIEZ, JULIE A, HOLT, LORI L · 2007 to 2021
$4.3M
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents with Depression: Toward Predictors of Treatment Response and Clinical CourseR01MH127176 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TIFFANY CHEING HO · 2022 to 2026
$3.1M
Integrated Clinical Neuroscience Training for Translational ResearchT32MH093311 · NIMH · FLORIDA STATE UNIVERSITY · PI LISA A ECKEL, Pamela K. Keel · 2012 to 2026
$2.3M
The Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881k
Examining Effort-Based Reward Processing and Lifetime Stress in Relation to Depression during AdolescenceF32MH125504 · NIMH · FLORIDA STATE UNIVERSITY · PI BRUSH, CHRISTOPHER · 2021 to 2022
$77k
NIGMS NIH HHS T32 GM081760NIMH NIH HHS F32 MH125504NIMH NIH HHS K01 MH117442NIMH NIH HHS R01 MH097767NIMH NIH HHS R01 MH127176NIMH NIH HHS R37 MH101495NIMH NIH HHS T32 MH093311
6 · The paper itself

Abstract

backgroundLife stress and blunted reward processing each have been associated with the onset and maintenance of major depressive disorder. However, much of this work has been cross-sectional, conducted in separate lines of inquiry, and focused on recent life stressor exposure, despite the fact that theories of depression posit that stressors can have cumulative effects over the lifespan. To address these limitations, we investigated whether acute and chronic stressors occurring over the lifespan interacted with blunted reward processing to predict increases in depression over time in healthy youth.

methodParticipants were 245 adolescent girls aged 8-14 years old (

resultsAs hypothesized, greater lifetime acute stressor exposure predicted increases in depressive symptoms over two years, but only for youth exhibiting a blunted RewP. This interaction, however, was not found for chronic stressors.

conclusionsLifetime acute stressor exposure may be particularly depressogenic for youth exhibiting a blunted RewP. Conversely, a robust RewP may be protective in the presence of greater acute lifetime stressor exposure.

Indexed as

DepressionMajor Depressive DisorderAdolescentChildCross-Sectional StudiesFemaleHealth StatusHumansRewardAdolescentDevelopmental PsychopathologyLife StressMajor Depressive DisorderRewardRewP

Identifiers

PMID37698514
PMCPMC10388334
OpenAlexW4288368491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.