ArticleMicrobiology spectrum2023
Composition and functional profiles of gut microbiota reflect the treatment stage, severity, and etiology of acute pancreatitis.
Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.Gut microbes · 2026Review
- Metagenomic profiling of gut microbiome in post-cholecystectomy patients with diarrhea: a nested case-control study.BMC microbiology · 2026Article
- Article
- Beyond the Pancreas: The Gut Microbiota in Acute Pancreatitis - From Mechanisms to Therapeutic Perspectives.Clinical and experimental gastroenterology · 2026Review
- In-depth investigation of the mechanism in rats with alcoholic acute pancreatitis via DNA methylation, intestinal flora, and fecal metabolomics.Journal of inflammation (London, England) · 2025Article
- Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis.BMJ open gastroenterology · 2025Observational
- Analysis of the overall development trends and hotspots in the research field of the human gut virome.Virology journal · 2025Review
- Metagenomics reveals functional profiles of gut microbiota during the recovery phase of acute pancreatitis.Scientific reports · 2025Article
- Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis.AMB Express · 2025Article
- Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis.Frontiers in immunology · 2025Article
- Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier.Frontiers in cellular and infection microbiology · 2025Article
- Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study.The journal of headache and pain · 2024Article
- The Characteristics of Gut Microbiota and Its Relation with Diet in Postmenopausal Osteoporosis.Calcified tissue international · 2024Article
- Impact of Geospatial Food Access on Acute Pancreatitis Outcomes.Digestive diseases and sciences · 2024Article
- Dysbiosis Signature of Fecal Microbiota in Patients with Pancreatic Adenocarcinoma and Pancreatic Intraductal Papillary Mucinous Neoplasms.Biomedicines · 2024Article
- Article
- The role of composition of gut microbiota in reflecting the severity of acute pancreatitis is probably overstated.Microbiology spectrum · 2024Article
- The Role of the Gut Microbiome in the Development of Acute Pancreatitis.International journal of molecular sciences · 2024Review
- Unravelling the role of gut microbiota in acute pancreatitis: integrating Mendelian randomization with a nested case-control study.Frontiers in microbiology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
importanceAcute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in the development and treatment of acute pancreatitis by affecting the host's metabolism. However, fewer studies acquired metagenomic sequencing data to associate species to functions intuitively and performed longitudinal analysis to explore how gut microbiota influences the development of AP. We followed 20 AP patients to generate longitudinal gut microbiota profiles and activity during disease and studied the differences in intestinal flora under different severities and etiologies. We have two findings. First, the gut microbiota profile has the potential to identify the severity and etiology of AP at an early stage. Second, gut microbiota likely acts synergistically in the development of AP. This study provides a reference for characterizing the driver flora of severe AP to identify the severity of acute pancreatitis at an early stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.