Evidence map›Paper›PMID 37698412›Full record

ArticlemBio2023

Daily fosfomycin versus levofloxacin for complicated urinary tract infections.

Nadine Rouphael, Patricia Winokur, Michael C Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G Fowler, Scott Evans, Randolph E Oler and 5 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. UropathogenicFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Nadine RouphaelEmory University School of Medicine , Atlanta, Georgia, USA.ORCID 0000-0002-2512-7919
Patricia WinokurDivision of Infectious Diseases, Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa, USA.
Michael C KeeferDivision of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York, USA.
Jessica TraenknerEmory University School of Medicine , Atlanta, Georgia, USA.
Ana DrobeniucEmory University School of Medicine , Atlanta, Georgia, USA.
Yohei DoiUniversity of Pittsburgh , Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9620-2525
Sonal MunsiffDivision of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York, USA.
Vance G FowlerAntibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
Scott EvansAntibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
Randolph E OlerThe Emmes Company, LLC , Rockville, Maryland, USA.
Bonifride TuyishimireThe Emmes Company, LLC , Rockville, Maryland, USA.
Marina LeeDivision of Microbiology and Infectious Diseases, NIAID, NIH , Rockville, Maryland, USA.
Varduhi GhazaryanDivision of Microbiology and Infectious Diseases, NIAID, NIH , Rockville, Maryland, USA.
Henry F ChambersAntibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
DMID 15-0045 study group
Emory University · USEmmes (United States) · USUniversity of Rochester · USUniversity of Iowa · USNational Institute of Allergy and Infectious Diseases · USNorthwestern Medicine · USDuke Medical Center · USGeorge Washington University · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
NCATS NIH HHS UL1 TR002378NIAID NIH HHS HHSN272201300018CNIAID NIH HHS HHSN272201300018INIAID NIH HHS HHSN272201300020INIAID NIH HHS HHSN272201300021CNIAID NIH HHS HHSN272201500002CNIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

importanceConcerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.

Indexed as

CystitisFosfomycinUrinary Tract InfectionsAnti-Bacterial AgentsHumansLevofloxacinAnti-Bacterial AgentsFosfomycinLevofloxacincomplicated UTIfosfomycinoral antibiotic

Identifiers

PMID37698412
PMCPMC10783529
OpenAlexW4386624254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.