Evidence map›Paper›PMID 37698169›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling.

Elise S Hibdon, Theresa M Keeley, Juanita L Merchant, Linda C Samuelson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elise S HibdonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Theresa M KeeleyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Juanita L MerchantDepartment of Medicine, University of Arizona, Tucson, Arizona, United States.
Linda C SamuelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-0898-2243
University of Michigan · USUniversity of Arizona · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
TRANSCRIPTIONAL CONTROL OF GASTRIN BY GROWTH FACTORSR01DK045729 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1993 to 2021
$4.1M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
Wnt Pathway Regulation of Gastric Stem Cell FunctionR01DK126451 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2022 to 2025
$2.0M
Wnt pathway regulation of human gastric stem cell functionK01DK111710 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HIBDON, ELISE · 2017 to 2018
$183k
NIDDK NIH HHS K01 DK111710NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK045729NIDDK NIH HHS R01 DK126451NIDDK NIH HHS T32 DK094775
6 · The paper itself

Abstract

Notch signaling regulates gastrointestinal stem cell proliferation and differentiation yet Notch-regulated transcriptional effectors of gastric epithelial cell differentiation are poorly understood. Here we tested the role of the bHLH transcription factor Achaete-Scute homolog 1 (ASCL1) in gastric epithelial cell differentiation, and its regulation by Notch. Newborn

Indexed as

GastrinsStomachAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationEnteroendocrine CellsMiceMice, KnockoutAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsGastrinsEC cellECL cellendocrine cell turnovergastric epithelial cell differentiationG cell

Identifiers

PMID37698169
PMCPMC10887855
OpenAlexW4386623720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.