Evidence map›Paper›PMID 37698050›Full record

ArticleJournal of cellular and molecular medicine2023

Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia.

Yu Chen, Wang Jiang, Jin-Mei Wang, Xiao-Di Ma, Di Wu, Le-Xin Liu, Ming Ji, Xiang-Ping Qu, Chi Liu, Hui-Jun Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yu ChenSchool of Basic Medicine, Central South University, Changsha, China.
Wang JiangSchool of Basic Medicine, Central South University, Changsha, China.
Jin-Mei WangSchool of Basic Medicine, Central South University, Changsha, China.
Xiao-Di MaSchool of Basic Medicine, Central South University, Changsha, China.
Di WuSchool of Basic Medicine, Central South University, Changsha, China.
Le-Xin LiuSchool of Basic Medicine, Central South University, Changsha, China.
Ming JiSchool of Basic Medicine, Central South University, Changsha, China.
Xiang-Ping QuSchool of Basic Medicine, Central South University, Changsha, China.
Chi LiuSchool of Basic Medicine, Central South University, Changsha, China.
Hui-Jun LiuSchool of Basic Medicine, Central South University, Changsha, China.
Xiao-Qun QinSchool of Basic Medicine, Central South University, Changsha, China.
Yang XiangSchool of Basic Medicine, Central South University, Changsha, China.ORCID 0000-0002-7865-2565
Central South University · CN

Funding

National Natural Science Foundation of China 81670002National Natural Science Foundation of China 81970033National Natural Science Foundation of China 82070034
6 · The paper itself

Abstract

Neonatal respiratory system disease is closely associated with embryonic lung development. Our group found that integrin β4 (ITGB4) is downregulated in the airway epithelium of asthma patients. Asthma is the most common chronic respiratory illness in childhood. Therefore, we suspect whether the deletion of ITGB4 would affect fetal lung development. In this study, we characterized the role of ITGB4 deficiency in bronchopulmonary dysplasia (BPD). ITGB4 was conditionally knocked out in CCSP-rtTA, Tet-O-Cre and ITGB4

Indexed as

AsthmaBronchopulmonary DysplasiaIntegrin beta4AnimalsEpithelial CellsGlycogen Synthase Kinase 3 betaHumansInfant, NewbornLungMiceMice, TransgenicWortmanninGlycogen Synthase Kinase 3 betaIntegrin beta4ITGB4 protein, humanItgb4 protein, mouseWortmanninBPDFAKGSK3βITGB4SOX2

Identifiers

PMID37698050
PMCPMC10718146
OpenAlexW4386624086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.