Evidence map›Paper›PMID 37697966›Full record

ArticleCNS neuroscience & therapeutics2024

The roles of apolipoprotein E ε4 on neuropathology and neuroinflammation in patients with Alzheimer's disease.

Mingyue He, Tenghong Lian, Peng Guo, Weijiao Zhang, Yanan Zhang, Yue Huang, Gaifen Liu, Huiying Guan, Jinghui Li, Dongmei Luo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Mingyue HeDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8825-3771
Tenghong LianDepartment of Neurology, Center for Cognitive Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng GuoDepartment of Neurology, Center for Cognitive Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Weijiao ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yanan ZhangDepartment of Blood Transfusion, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yue HuangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Gaifen LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Huiying GuanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jinghui LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dongmei LuoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Weijia ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wenjing ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing QiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hao YueDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaomin WangDepartment of Physiology, Capital Medical University, Beijing, China.
Wei ZhangDepartment of Neurology, Center for Cognitive Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

Basic-Clinical Research Cooperation Funding of Capital Medical University, China (2015-JL-PT-X04, 10-JL-49, 14-JL-15)Beijing Healthcare Research Project, China (JING-15-2)Capital Clinical Characteristic Application Research (Z121107001012161)Capital's Funds for Health Improvement and Research (CFH) (2022-2-2048)Excellent Personnel Training Project of Beijing, China (20071D0300400076)High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26)Key Project of Natural Science Foundation of Beijing, China (4161004)Key Technology R&D Program of Beijing Municipal Education Commission (kz201610025030)National Key Research and Development Program of China (2016YFC1306300, 2016YFC1306000)National Natural Science Foundation of China (81970992, 81571229, 81071015, 30770745, 82201639)Natural Science Foundation of Beijing, China (7082032)Natural Science Foundation of Capital Medical University, Beijing, China (PYZ2018077)Project of Beijing Institute for Brain Disorders (BIBD-PXM2013_014226_07_000084)Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514)Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing (JJ2018-48)The National Key R&D Program of China-European Commission Horizon 2020 (2017YFE0118800-779238)Youth Research Funding, Beijing Tiantan Hospital, Capital Medical University, China (2015-YQN-14, 2015-YQN-15, 2015-YQN-17)
6 · The paper itself

Abstract

aimsTo explore the roles of apolipoprotein E (APOE) ε4 on the neuropathology and neuroinflammation in Alzheimer's disease (AD) patients.

methodsAD patients were divided into the APOE ε4 carrier and the APOE ε4 non-carrier groups according to APOE genotype. Demographic information, cognitive function, the levels of neuropathological proteins and neuroinflammatory factors in cerebrospinal fluid (CSF) were compared between the two groups, and their correlations were subsequently analyzed.

resultsβ amyloid protein (Aβ)

conclusionAPOE ε4 is associated with poorer cognition, particularly the early symptoms of memory, language, and attention. APOE ε4 is associated with lower Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E4Apolipoproteins EGenotypeHumansNeuroinflammatory DiseasesAmyloid beta-PeptidesApoE protein, humanApolipoprotein E4Apolipoproteins EAlzheimer's diseaseapolipoprotein E ε4cognitive functionneuroinflammatory factorsneuropathological proteins

Identifiers

PMID37697966
PMCPMC10916449
OpenAlexW4386623694

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.