Evidence map›Paper›PMID 37697956›Full record

ArticleCNS neuroscience & therapeutics2024

CD8

Jun Wang, Qinghao Zhu, Yan Shen, Jiao Liang, Yi Wang, Yuxiao Huang, Guodong Tong, Xu Wang, Ningning Zhang, Kangjie Yu and 2 more

Open access · goldAbstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  7. CXCL10CNS neuroscience & therapeutics · 2025
    Article
  8. Article
  9. CD8CNS neuroscience & therapeutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jun WangDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.ORCID 0000-0003-0880-4663
Qinghao ZhuDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Yan ShenDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.ORCID 0000-0001-7058-8602
Jiao LiangDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.ORCID 0000-0002-4013-7322
Yi WangDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Yuxiao HuangDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Guodong TongDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Xu WangSchool of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Ningning ZhangSchool of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Kangjie YuDepartment of Pathology, Air Force Hospital of Eastern Theater, Nanjing, China.
Yinghui LiDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Ya ZhaoDepartment of Medical Microbiology and Parasitology, Fourth Military Medical University, Xi'an, China.
Air Force Medical University · CNAir Force General Hospital PLA · CNNorthwest University · CN

Funding

National Natural Science Foundation of China 81702019National Natural Science Foundation of China 82002158National Natural Science Foundation of China 82072298Natural Science Foundation of Shaanxi Province 2017SF-192Natural Science Foundation of Shaanxi Province 2019JQ-408
6 · The paper itself

Abstract

introductionCerebral malaria (CM) is a lethal neuroinflammatory disease caused by Plasmodium infection. Immune cells and brain parenchyma cells contribute to the pathogenesis of CM. However, a systematic examination of the changes that occur in the brain parenchyma region during CM at the single-cell resolution is still poorly studied.

aimsTo explore cell composition and CD8

resultsThe brainstem is the most severely damaged site during ECM. ScRNA-seq revealed a large number of CD8

conclusionsThese findings reveal a novel interaction between brain-infiltrated CD8

Indexed as

CD8-Positive T-LymphocytesMalaria, CerebralAnimalsB7-H1 AntigenBrain StemCell ProliferationMiceProgrammed Cell Death 1 ReceptorB7-H1 AntigenProgrammed Cell Death 1 Receptorastrocytesbrain-infiltrated CD8+ T cellbrainstemexperimental cerebral malariaPD-1/PD-L1 pathwaysingle-cell RNA sequencing

Identifiers

PMID37697956
PMCPMC10916431
OpenAlexW4386624564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.