Evidence map›Paper›PMID 37697923›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma.

Min-Ae Song, Ji Young Kim, Matthew W Gorr, Roy A Miller, Manjula Karpurapu, Jackie Nguyen, Devki Patel, Kellie J Archer, Navjot Pabla, Peter G Shields and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  6. Article
  7. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  8. Review
  9. The Asthma Risk Gene,Journal of respiratory biology and translational medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Min-Ae SongDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States.
Ji Young KimDivision of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-3736-9050
Matthew W GorrDivision of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0001-7561-6481
Roy A MillerDivision of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio, United States.
Manjula KarpurapuDivision of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Jackie NguyenDivision of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Devki PatelDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States.
Kellie J ArcherDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, United States.
Navjot PablaDivision of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States.
Peter G ShieldsComprehensive Cancer Center, The Ohio State University and James Cancer Hospital, Columbus, Ohio, United States.ORCID 0000-0002-7404-217X
Loren E WoldDivision of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0001-8155-0204
John W ChristmanDivision of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0001-6926-9313
Sangwoon ChungDivision of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0003-4484-8268
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN ARDSR01HL137224 · NHLBI · OHIO STATE UNIVERSITY · PI CHRISTMAN, JOHN W, KARPURAPU, MANJULA · 2018 to 2025
$4.5M
Defining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9M
Mitochondrial Genetic Alterations: A clinical trial of a standardized research e-cigaretteR21HL147401 · NHLBI · OHIO STATE UNIVERSITY · PI SONG, MIN-AE · 2019 to 2020
$429k
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL137224NHLBI NIH HHS R01 HL139348NHLBI NIH HHS R21 HL147401
6 · The paper itself

Abstract

The prevalence of electronic cigarette (EC) use among adult with asthma has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with preexisting asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of patients with asthma. To define the consequences of EC exposure in established asthma, we used a mouse model with/without preexisting asthma for short-term exposure to EC aerosols. C57/BL6J mice were sensitized and challenged with a DRA (dust mite, ragweed,

Indexed as

AsthmaElectronic Nicotine Delivery SystemsPneumoniaAdultAnimalsDisease Models, AnimalDNA, MitochondrialFemaleHumansInflammationLungMaleMiceNicotineRespiratory Aerosols and DropletsDNA, MitochondrialNicotineairway inflammationasthmaelectronic cigarettesmitochondrial DNA contentsex differences

Identifiers

PMID37697923
PMCPMC11068405
OpenAlexW4386624604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.