SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2023
Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study.
Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial.Acta pharmaceutica Sinica. B · 2026Article
- Antidepressants and the risk of hyponatremia: A multi-institutional cohort study using observational medical outcomes partnership-Common Data Model.British journal of clinical pharmacology · 2026Observational
- Estrogen Replacement Therapy in Ovariectomized Rats: Complementary Roles of ER and GPR30 in Alleviating Depressive-like Behavior.Current issues in molecular biology · 2026Article
- The association between age at menopause and circadian syndrome: a study based on the UK Biobank.BMC public health · 2026Article
- Proactive health management and psychological distress among perimenopausal women: A cross-sectional latent profile and mediation analysis.Scientific reports · 2026Article
- Quality of Life, Menopausal Symptoms, Insomnia and Depression in Peri- and Post-Menopausal Women: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Hormone therapy and psychosocial factors in menopausal women with painful TMD: a pilot cross-sectional study.Journal of applied oral science : revista FOB · 2026Article
- Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation study.npj women's health · 2026Article
- Stress, Anxiety, and Self-Efficacy in Hypertension: Evidence from a Romanian Case-Control Study.Diseases (Basel, Switzerland) · 2025Article
- High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression.Acta pharmaceutica Sinica. B · 2025Article
- Pelvic floor symptom progression increases risk for depression, while better physical performance is protective in Asian midlife women.Scientific reports · 2025Article
- Comparison of the efficacy and safety of bupropion versus aripiprazole augmentation in adults with treatment-resistant depression: a nationwide cohort study in South Korea.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Observational
- A study on anxiety and depression symptoms among menopausal women: a web based cross sectional survey.Frontiers in public health · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundThe menopause transition is a vulnerable period that can be associated with changes in mood and cognition. The present study aimed to investigate whether a symptomatic menopausal transition increases the risks of depression, anxiety, and sleep disorders.
methodsThis population-based, retrospective cohort study analysed data from five electronic health record databases in South Korea. Women aged 45-64 years with and without symptomatic menopausal transition were matched 1:1 using propensity-score matching. Subgroup analyses were conducted according to age and use of hormone replacement therapy (HRT). A primary analysis of 5-year follow-up data was conducted, and an intention-to-treat analysis was performed to identify different risk windows over 5 or 10 years. The primary outcome was first-time diagnosis of depression, anxiety, and sleep disorder. We used Cox proportional hazard models and a meta-analysis to calculate the summary hazard ratio (HR) estimates across the databases.
resultsPropensity-score matching resulted in a sample of 17,098 women. Summary HRs for depression (2.10; 95% confidence interval [CI] 1.63-2.71), anxiety (1.64; 95% CI 1.01-2.66), and sleep disorders (1.47; 95% CI 1.16-1.88) were higher in the symptomatic menopausal transition group. In the subgroup analysis, the use of HRT was associated with an increased risk of depression (2.21; 95% CI 1.07-4.55) and sleep disorders (2.51; 95% CI 1.25-5.04) when compared with non-use of HRT.
conclusionsOur findings suggest that women with symptomatic menopausal transition exhibit an increased risk of developing depression, anxiety, and sleep disorders. Therefore, women experiencing a symptomatic menopausal transition should be monitored closely so that interventions can be applied early.
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