Evidence map›Paper›PMID 37697642›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation.

Tomoyuki Suezawa, Naoko Sasaki, Yuichi Yukawa, Nazgul Assan, Yuta Uetake, Kunishige Onuma, Rino Kamada, Daisuke Tomioka, Hidehiro Sakurai, Ryohei Katayama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sprayable Hydrogel Dressings in Wound-Healing Applications.Bioengineering (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Tomoyuki SuezawaDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Naoko SasakiJoint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yuichi YukawaDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nazgul AssanDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yuta UetakeDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kunishige OnumaDepartment of Clinical Bio-resource Research and Development, Kyoto University Graduate School of Medicine, Kyoto, 606-8304, Japan.
Rino KamadaDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Daisuke TomiokaDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hidehiro SakuraiDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ryohei KatayamaDivision of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Masahiro InoueDepartment of Clinical Bio-resource Research and Development, Kyoto University Graduate School of Medicine, Kyoto, 606-8304, Japan.
Michiya MatsusakiDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.ORCID 0000-0003-4294-9313
The University of Osaka · JPKyoto University · JPChemotherapy Foundation · US

Funding

Japan Agency for Medical Research and Development JP22ama221201h0001Japan Agency for Medical Research and Development JP22ama221210h0001JSPS Grant-in-Aid for Challenging Exploratory Research 22K19918JSPS Grant-in-Aid for Early-Career Scientists 20K15279JSPS Grant-in-Aid for Scientific Research (A) 20H00665JSPS Grant-in-Aid for Scientific Research (C) 22K05095JST-COI-NEXT JPMJPF2009JST-Mirai-Program 18077228New Energy and Industrial Technology Development Organization JPNP20004
6 · The paper itself

Abstract

Collagen is the most abundant protein in the human body and one of the main components of stromal tissues in tumors which have a high elastic modulus of over 50 kPa. Although collagen has been widely used as a cell culture scaffold for cancer cells, there have been limitations when attempting to fabricate a tough collagen gel with cells like a cancer stroma. Here, rapid gelation of a collagen solution within a few minutes by transition metal complexation is demonstrated. Type I collagen solution at neutral pH shows rapid gelation with a transparency of 81% and a high modulus of 1,781 kPa by mixing with K

Indexed as

CollagenExtracellular MatrixCell Culture TechniquesGelsHumansIonsCollagenGelsIons3D-cell culturecollagenhealing propertyrapid gelationtransparency

Identifiers

PMID37697642
PMCPMC10602541
OpenAlexW4386624266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.