ArticleEuropean journal of medical research2023
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The risk of thyroid diseases in lichen sclerosus patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus.Andrology · 2026Article
- Clinical presentation differences of lichen sclerosus in pre- and post-menopausal women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026Article
- Lichen sclerosus in paediatric patients with phimosis undergoing circumcision.Skin health and disease · 2025Article
- Histologically verified penile lichen sclerosus-Incidence in Denmark over 26 years and long-term risk of penile and non-penile cancer.International journal of cancer · 2025Article
- The age-related incidence of male genital lichen sclerosus is triphasic.Skin health and disease · 2024Article
- Development and Validation of a Machine Learning-Based Early Warning Model for Lichenoid Vulvar Disease: Prediction Model Development Study.Journal of medical Internet research · 2024Article
- Management of Lichen Sclerosus and Related Comorbidities at a Tertiary Referral Center: Beyond Topical Steroids.Dermatology practical & conceptual · 2024Article
- A Preliminary Study Using High-Frequency Ultrasound to Evaluate Vulvar Skin With Lichenoid Vulvar Dermatoses.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Alopecia areata is associated with lichen planus and lichen sclerosus in a case-control study of 4,785 patients.Archives of dermatological research · 2024Article
- Blue diode laser as supportive therapy for the management of vulvar lichen sclerosus.Dermatology reports · 2024Article
- The Association between Cardiovascular Risk Factors and Lichen Sclerosus: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Lichen Sclerosus-Incidence and Comorbidity: A Nationwide Swedish Register Study.Journal of clinical medicine · 2024Article
- [Genital lichen sclerosus and lichen planus].Dermatologie (Heidelberg, Germany) · 2024Review
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3 authors.
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Abstract
Lichen sclerosus (LS) is a chronic lymphocyte mediated inflammatory mucocutaneous disease of unknown aetiology with a predilection for the anogenital region, and affecting both sexes. The disease is characterized by pain, intolerable itching and scarring. In late stages of LS, disfiguring scarring can drastically alter the structural anatomical architecture of the genitals. The association between genital LS and different malignant tumours is a concern that needs to be further investigated. An association between LS and several autoimmune diseases has been confirmed in recent studies. All registered citizens of Region Jönköping, Sweden were included in the present study. Patients diagnosed with LS (n = 5680) between 2001 and 2021 were identified using ICD-10 code L90.0 and selected as cases. All other individuals (n = 362 568) served as controls. Odds ratios (ORs) for the selected comorbidity were calculated and adjusted for age and sex. The cumulative incidence of LS for the entire population over a 20-year period was 1.54% (15.4 per 1000 people). The cumulative incidences over a 20-year period for females and males were 2.13% and 0.97%, respectively. This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1-25.3), penis cancer (OR = 9.1; 95% CI 4.3-18.9), prostate cancer (OR = 2.0; 95% CI 1.6-2.4) and breast cancer (OR = 1.6; 95% CI 1.4-1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6-2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6-2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient treatment and follow-up of patients with LS. However, future studies are needed to confirm these results and the potential role of LS in the development of cancer.
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