Evidence map›Paper›PMID 37697349›Full record

ArticleDiagnostic pathology2023

Detection of extraprostatic extension by transperineal multiparametric magnetic resonance imaging-ultrasound fusion targeted combined with systemic template prostate biopsy.

Hao-Wen Chuang, Shulin Wu, Sharron X Lin, Ting Zhao, Michelle M Kim, Mukesh Harisinghani, Adam S Feldman, Douglas M Dahl, Chin-Lee Wu

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Article in Diagnostic pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hao-Wen ChuangDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shulin WuDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sharron X LinDepartment of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ting ZhaoDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Michelle M KimDepartment of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mukesh HarisinghaniDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Adam S FeldmanDepartment of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Douglas M DahlDepartment of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ddahl@mgh.harvard.edu.
Chin-Lee WuDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. cwu2@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtraprostatic extension (EPE) of prostate cancer (PCa) on transrectal (TR) needle core biopsy (Bx) is a rare histopathological finding that can help in clinical decision-making. The detection efficiency of the transperineal (TP) approach is yet to be explored.

methodsWe retrospectively reviewed 2848 PCa cases using concomitant systemic template biopsy (SBx) and multiparametric magnetic resonance imaging (MRI)-ultrasound fusion-targeted biopsy (TBx) using the TR (n = 1917) or TP (n = 931) approach at our institution between January 2015 and July 2022. We assessed and compared clinical, MRI, and biopsy characteristics using different approaches (TP and TR) and methods (SBx and TBx).

resultsIn total, 40 EPE cases were identified (40/2848, 1.4%). TP showed a significantly higher EPE detection rate compared to TR in SBx (TR:0.7% vs. TP:1.6%; p = 0.028) and TBx (TR:0.5% vs. TP:1.2%; p = 0.033), as well as the combined methods (2.1% vs. 1.1%, p = 0.019). A significantly higher incidence of EPEs was found at non-base sites in TP than in TR (76.7% vs. 50%, p = 0.038). SBx showed a higher EPE detection rate than TBx; however, the difference was not statistically significant. TP showed higher prostate-specific antigen density (0.35 vs. 0.17, p = 0.005), higher frequency of GG4-5 in the cores with EPE (65.0% vs. 50.0%, p = 0.020), and more PCa-positive SBx cores (10 vs. 8, p = 0.023) compared to the TR.

conclusionsTP may improve EPE detection compared with TR and should be applied to patients with adverse pre-biopsy features.

Indexed as

Multiparametric Magnetic Resonance ImagingProstatic NeoplasmsHumansImage-Guided BiopsyMaleProstateRetrospective StudiesExtraprostatic extensionFusion biopsyProstate cancerTemplateTransperinealTransrectal

Identifiers

PMID37697349
PMCPMC10494402

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